Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe

Lamichhane, SantoshTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)

Gut metabolome meets microbiome : A methodological perspective to understand the relationship between host and microbe

Funding Agencies:Juvenile Diabetes Research Foundation 2-SRA-2014-159-Q-R Academy of Finland 292568
It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.

Sen, ParthoTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)
Dickens, Alex M.Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)
Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
Bertram, Hanne ChristineDepartment of Food Science, Aarhus University, Aarslev, Denmark (författare)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FinlandInstitutionen för medicinska vetenskaper (creator_code:org_t)

Av författaren/redakt...: Lamichhane, Sant ...; Sen, Partho; Dickens, Alex M.; Oresic, Matej, 1 ...; Bertram, Hanne C ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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