onr:"swepub:oai:DiVA.org:oru-76142"
Sökning: onr:"swepub:oai:DiVA.org:oru-76142" > Molecular epidemiol...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Månsson, Emeli,1978-Örebro universitet,Institutionen för medicinska vetenskaper (författare)
Molecular epidemiology of Staphylococcus epidermidis in prosthetic joint infections
- BokEngelska2019
Förlag, utgivningsår, omfång ...
- Örebro :Örebro University,2019
- 137 s.
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-76142
- ISBN:9789175293097
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76142URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Serie
- Örebro Studies in Medicine,1652-4063 ;203
Anmärkningar
- Staphylococcus epidermidis is ubiquitous in the human microbiota, but also an important pathogen in healthcare-associated infections, such as prosthetic joint infections (PJIs). In this thesis, aspects of the molecular epidemiology of S. epidermidis in PJIs were investigated with the aim of improving our understanding of the pre- and perioperative measures required to reduce the incidence of S. epidermidis PJIs.In Paper I, S. epidermidis retrieved from air sampling in the operating field during arthroplasty was characterized by multilocus sequence typing and antibiotic susceptibility testing. No isolates belonging to sequence types (STs) 2 and 215, previously associated with PJIs, were found in the air of the operating field. During air sampling, several Staphylococcus pettenkoferi isolates were identified, and as a spin-off of Paper I, the genomic relatedness of these isolates to S. pettenkoferi isolates from blood cultures was described in Paper II.In Paper III, genetic traits distinguishing S. epidermidis isolated from PJIs were determined using genome-wide association study accounting for population effects after whole-genome sequencing (WGS) of a population- based 10-year collection of S. epidermidis isolates from PJIs and of nasal isolates retrieved from patients scheduled for arthroplasty. Genes associated with antimicrobial agents used for prophylaxis in arthroplasty, i.e., beta-lactam antibiotics, aminoglycosides, and chlorhexidine, were associated with PJI origin. S. epidermidis from PJIs were dominated by the ST2a, ST2b, ST5, and ST215 lineages.In Paper IV, selective agar plates were used to investigate colonization with methicillin resistant S. epidermidis (MRSE) in patients scheduled for arthroplasty. MRSE were further characterized by WGS. A subset of patients was found to harbour PJI-associated S. epidermidis lineages in their microbiota before hospitalization, but no isolates belonging to the ST2a lineage nor any rifampicin-resistant isolates were retrieved.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
- Staphylococcus epidermidis
- molecular epidemiology
- prosthetic joint infections
- whole genome sequencing
- Staphylococcus pettenkoferi
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Söderquist, Bo,professor,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)bost (preses)
- Sundqvist, Martin,med. dr.1974-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)mist (preses)
- Nilsdotter-Augustinsson, Åsa,docentLinköping University, Norrköping, Sweden (preses)
- Särndahl, Eva,professor,1963-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)easl (preses)
- Bergh, Kåre,professorDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway (opponent)
- Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Internetlänk
- https://oru.diva-portal.org/smash/get/diva2:1348975/PREVIEW01.pngpreview image
- https://oru.diva-portal.org/smash/get/diva2:1348975/COVER01.pdfcover
- https://oru.diva-portal.org/smash/get/diva2:1348975/FULLTEXT01.pdffulltext
- https://oru.diva-portal.org/smash/get/diva2:1348975/SPIKBLAD01.pdfspikblad
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76142
Hitta via bibliotek
- Molecular epidemiology of Staphylococcus epidermidis in prosthetic joint infecti... (Sök publikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Månsson, Emeli, ...
- Söderquist, Bo, ...
- Sundqvist, Marti ...
- Nilsdotter-Augus ...
- Särndahl, Eva, p ...
- Bergh, Kåre, pro ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Allmänmedicin
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Infektionsmedici ...
- Delar i serien
- Örebro Studies i ...
- Av lärosätet
- Örebro universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
