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Sökning: onr:"swepub:oai:DiVA.org:oru-76639" > A prospective study...

  • Zhang, YiwenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)

A prospective study of intraprostatic inflammation, focal atrophy, and progression to lethal prostate cancer

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-76639
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76639URI
  • https://doi.org/10.1158/1055-9965.EPI-19-0713DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Cancer Center Support Grants from the NCI  P30 CA006516 P30 CA006973Emory, Harvard and University of Washington Prostate Cancer Biomarker Center  U01 CA113913   U01 CA167552
  • BACKGROUND: Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance.METHODS: In the Health Professionals Follow-Up Study and Physicians' Health Study, we studied 1,035 men diagnosed with prostate cancer. A genitourinary pathologist centrally reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and four subtypes of focal atrophy. Cox proportional hazards models adjusted for potential confounders were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of these features with lethal prostate cancer, defined as development of metastatic disease or death during follow-up.RESULTS: During a median of 12 years of follow-up, 153 men developed lethal prostate cancer. Eighty-four percent of men had histologic evidence of chronic inflammation and 30% had acute inflammation. Both chronic and acute inflammation were inversely associated with lethal prostate cancer in age- and lifestyle-adjusted models. Chronic inflammation remained inversely associated with lethal prostate cancer after additionally adjusting for prognostic clinical features (HR=0.45, 95% CI 0.30 to 0.69 for mild, HR=0.51, 95% CI 0.33 to 0.80 for moderate to severe). None of the atrophic lesions were associated with lethal prostate cancer.CONCLUSIONS: Our data suggest that the presence of inflammation, particularly chronic inflammation, in prostate cancer tissue is associated with better prognosis among prostate cancer patients.IMPACT: This is the largest prospective cohort study to examine the association between inflammation, focal atrophy, and lethal prostate cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhou, Cindy KeEpidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Rencsok, Emily M.Health Sciences & Technology, Harvard Medical School, Boston MA, USA (författare)
  • Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)kafl (författare)
  • Lotan, Tamara L.Department of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA (författare)
  • Loda, MassimoPathologist-in-Chief, Weill Cornell Medicine, New York NY, USA (författare)
  • Giunchi, FrancescaPathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy (författare)
  • Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, USA (författare)
  • De Marzo, Angelo M.Department of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA (författare)
  • Mucci, Lorelei ADepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Fiorentino, MichelangeloPathology Service, University of Bologna, Bologna, Italy (författare)
  • Ebot, Ericka M.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USAEpidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research28:12, s. 2047-20541055-99651538-7755

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