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Sökning: onr:"swepub:oai:DiVA.org:oru-78629" > The familial co-agg...

  • Song, HuanCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (författare)

The familial co-aggregation of stress-related disorders and autoimmune diseases

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-10-22
  • Springer,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-78629
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78629URI
  • https://doi.org/10.1007/s10519-019-09973-8DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Evidence has emerged indicating a role of stress-related disorders in the development of autoimmune diseases. However, it remains unknown whether genetic components contribute to the observed association. We therefore investigated the co-aggregation of stress-related disorders and autoimmune diseases in individuals and their family members in the Swedish population.Methods: We identified 4,123,631 individuals born in Sweden between 1953 and 1993. Based on information from the Multi-Generation Register, we conducted cohorts of relatives of varying relatedness. Logistic regression was used to estimate the association between clinical ascertained stress-related disorders (i.e., acute stress reaction, posttraumatic stress disorder [PTSD], adjustment disorder, and other severe stress reactions) and autoimmune diseases (36 different types) in individuals and in families, presenting relative risks as odds ratios (ORs).Results: Individuals with stress-related disorder were at high er risk of having autoimmune diseases compared with individuals who did nothave stress-related disorder (OR = 1.66, 95% confidence intervals (CI) 1.63–1.69). Within families, the association seemed strongest between monozygotic twins (OR = 1.47, 95% CI 1.07–2.03), and then decreased with descending dyads of familial/genetic relatedness ̄OR was 1.28 (95% CI 0.97–1.67), 1.16 (95% CI 1.14–1.18), 1.05 (95% CI 1.02–1.09), 1.06 (95% CI 1.03–1.10), 1.05 (95% CI 1.04–1.06), and 1.00 (95% CI 0.98–1.04) for dizygotic twins, full siblings, maternal half siblings, paternal half siblings, full cousins, and half cousins, respectively. Further analyses on PTSD and autoimmune diseases obtained similar estimates.Conclusion: The pattern of the association across twin zygosity and varying familial relatedness supports the hypothesis of a genetic overlap between stress-related disorders and autoimmune diseases which warrants further exploration.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yao, YuyangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (författare)
  • Fang, FangKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (författare)
  • Lichtenstein, PaulKarolinska Institutet, Stockholm, Sweden (författare)
  • D'Onofrio, BrianIndiana University, Bloomingto IN, USA (författare)
  • Almqvist, CatarinaKarolinska Institutet, Stockholm, Sweden (författare)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hiln (författare)
  • Valdimarsdottir, UnnurCenter of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (författare)
  • Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, IcelandKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Behavior Genetics: Springer49:6, s. 539-5400001-82441573-3297

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