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Comorbidity of subs...
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Virtanen, SuviKarolinska Institutet
(författare)
Comorbidity of substance misuse with anxiety-related and depressive disorders : a genetically informative population study of 3 million individuals in Sweden
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Cambridge University Press,2020
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-79522
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79522URI
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https://doi.org/10.1017/S0033291719001788DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144394858URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council under the grant no 2017-00641. This study was supported by funding from the Academy of Finland grants 308698 and 314196.
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BACKGROUND: Causes of the comorbidity of substance misuse with anxiety-related and depressive disorders (anxiety/depression) remain poorly known. We estimated associations of substance misuse and anxiety/depression in the general population and tested them while accounting for genetic and shared environmental factors.METHODS: We studied individuals born in Sweden 1968-1997 (n = 2 996 398) with follow-up in nationwide register data for 1997-2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs. Substance misuse was defined as ICD-10 alcohol or drug use disorder or an alcohol/drug-related criminal conviction. Three dimensions of ICD-10 anxiety and depressive disorders and a substance misuse dimension were identified through exploratory factor analysis.RESULTS: Substance misuse was associated with a 4.5-fold (95% CI 4.50-4.58) elevated risk of lifetime generalized anxiety/depression, 4.7-fold (95% CI 4.63-4.82) elevated risk of panic disorder and agora/social phobia, and 2.9-fold elevated risk of phobias/OCD (95% CI 2.82-3.02) as compared to those without substance misuse. The associations were attenuated in within-family analyses but we found elevated risks in monozygotic twin pairs discordant for substance misuse as well as significant non-shared environmental correlations. The association between anxiety/depression and substance misuse was mainly driven by generalized anxiety/depression, whereas other anxiety/depression dimensions had minor or no independent associations with substance misuse.CONCLUSIONS: Substance misuse and anxiety/depression are associated at the population level, and these associations are partially explained by familial liabilities. Our findings indicate a common genetic etiology but are also compatible with a potential partially causal relationship between substance misuse and anxiety/depression.
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Kuja-Halkola, RalfKarolinska Institutet
(författare)
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Mataix-Cols, DavidKarolinska Institutet
(författare)
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Jayaram-Lindström, NityaKarolinska Institutet
(författare)
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D'Onofrio, Brian M.Karolinska Institutet
(författare)
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Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln
(författare)
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Rück, ChristianKarolinska Institutet
(författare)
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Suvisaari, JaanaNational Institute for Health and Welfare, Helsinki, Finland
(författare)
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Lichtenstein, PaulKarolinska Institutet
(författare)
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Latvala, AnttiKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Psychological Medicine: Cambridge University Press50:10, s. 1706-17150033-29171469-8978
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Virtanen, Suvi
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Kuja-Halkola, Ra ...
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Mataix-Cols, Dav ...
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D'Onofrio, Brian ...
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Larsson, Henrik, ...
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Rück, Christian
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Suvisaari, Jaana
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Lichtenstein, Pa ...
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Latvala, Antti
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