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  • Stenmark, Bianca,1987-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine (författare)

Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-02-27
  • Nature Publishing Group,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-80302
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80302URI
  • https://doi.org/10.1038/s41598-020-59509-yDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:"Functional Genomics" program of the Research Council of Norway  "Infrastructure" program of the Research Council of Norway  Southeastern Regional Health Authorities European Union (EU)Örebro County Council Research Committee  Nyckelfonden  Örebro University 
  • Invasive meningococcal disease (IMD) due to serogroup Y Neisseria meningitidis emerged in Europe during the 2000s. Draft genomes of serogroup Y isolates in Sweden revealed that although the population structure of these isolates was similar to other serogroup Y isolates internationally, a distinct strain (YI) and more specifically a sublineage (1) of this strain was responsible for the increase of serogroup Y IMD in Sweden. We performed single molecule real-time (SMRT) sequencing on eight serogroup Y isolates from different sublineages to unravel the genetic and epigenetic factors delineating them, in order to understand the serogroup Y emergence. Extensive comparisons between the serogroup Y sublineages of all coding sequences, complex genomic regions, intergenic regions, and methylation motifs revealed small point mutations in genes mainly encoding hypothetical and metabolic proteins, and non-synonymous variants in genes involved in adhesion, iron acquisition, and endotoxin production. The methylation motif CACNNNNNTAC was only found in isolates of sublineage 2. Only seven genes were putatively differentially expressed, and another two genes encoding hypothetical proteins were only present in sublineage 2. These data suggest that the serogroup Y IMD increase in Sweden was most probably due to small changes in genes important for colonization and transmission.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Harrison, Odile B.Department of Zoology, University of Oxford, Oxford, United Kingdom (författare)
  • Eriksson, Lorraine,1990-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine(Swepub:oru)loen (författare)
  • Anton, Brian P (författare)
  • Fomenkov, AlexeyNew England Biolabs, Ipswich, Massachusetts, USA (författare)
  • Roberts, Richard J.New England Biolabs, Ipswich, Massachusetts, USA (författare)
  • Tooming-Klunderud, AveCentre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo, Norway. (författare)
  • Bratcher, Holly B.Department of Zoology, University of Oxford, Oxford, United Kingdom (författare)
  • Bray, James E.Department of Zoology, University of Oxford, Oxford, United Kingdom (författare)
  • Thulin-Hedberg, SaraDepartment of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
  • Maiden, Martin C. J.Department of Zoology, University of Oxford, Oxford, United Kingdom (författare)
  • Mölling, PaulaDepartment of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scientific Reports: Nature Publishing Group10:12045-2322

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