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Cortical burst dyna...
Cortical burst dynamics predict clinical outcome early in extremely preterm infants
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- Iyer, Kartik K. (författare)
- QIMR Berghofer Medical Research Institute, Brisbane, Australia; Faculty of Medicine and Biomedical Sciences, University of Queensland, Australia
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- Roberts, James A. (författare)
- QIMR Berghofer Medical Research Institute, Brisbane, Australia
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- Hellström-Westas, Lena (författare)
- Uppsala universitet,Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wikström, Sverre, 1978- (författare)
- Department of Paediatrics, Karlstad Central Hospital, Karlstad, Sweden
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- Pupp, Ingrid (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ley, David (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Vanhatalo, Sampsa (författare)
- Department of Children's Clinical Neurophysiology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland; Department of Paediatrics, Children's Hospital, University Central Hospital, University of Helsinki, Helsinki, Finland
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- Breakspear, Michael (författare)
- QIMR Berghofer Medical Research Institute, Brisbane, Australia; Royal Brisbane and Women's Hospital, Brisbane, Australia
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(creator_code:org_t)
- 2015-05-22
- 2015
- Engelska.
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Ingår i: Brain. - : Oxford University Press. - 0006-8950 .- 1460-2156. ; 138:Pt 8, s. 2206-2218
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Intermittent bursts of electrical activity are a ubiquitous signature of very early brain activity. Previous studies have largely focused on assessing the amplitudes of these transient cortical bursts or the intervals between them. Recent advances in basic neuroscience have identified the presence of scale-free 'avalanche' processes in bursting patterns of cortical activity in other clinical contexts. Here, we hypothesize that cortical bursts in human preterm infants also exhibit scale-free properties, providing new insights into the nature, temporal evolution, and prognostic value of spontaneous brain activity in the days immediately following preterm birth. We examined electroencephalographic recordings from 43 extremely preterm infants (gestational age 22-28 weeks) and demonstrated that their cortical bursts exhibit scale-free properties as early as 12 h after birth. The scaling relationships of cortical bursts correlate significantly with later mental development-particularly within the first 12 h of life. These findings show that early preterm brain activity is characterized by scale-free dynamics which carry developmental significance, hence offering novel means for rapid and early clinical prediction of neurodevelopmental outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- preterm
- bursts
- scale-free
- spontaneous activity transient
- long-term outcome
- brain monitoring
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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