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Genomic epidemiolog...
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Golparian, Daniel,1984-Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology
(författare)
Genomic epidemiology of Neisseria gonorrhoeae elucidating the gonococcal antimicrobial resistance and lineages/sublineages across Brazil, 2015-16
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-08-12
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Oxford University Press,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-85106
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85106URI
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https://doi.org/10.1093/jac/dkaa318DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:Örebro County Council Research Committee Foundation for Medical Research at Orebro University Hospital, Örebro, Sweden Brazilian Ministry of Health, through its Secretariat for Health Surveillance Brazilian Ministry of Health, through its Department of Chronic Conditions and Sexually Transmitted Infection
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OBJECTIVES: Neisseria gonorrhoeae antimicrobial resistance (AMR) surveillance is imperative internationally, but only eight (22.9%) countries in the WHO Region of the Americas reported complete AMR data to the WHO Global Gonococcal Antimicrobial Surveillance Program (WHO GASP) in 2016. Genomic studies are ideal for enhanced understanding of gonococcal populations, including the spread of AMR strains. To elucidate the circulating gonococcal lineages/sublineages, including their AMR determinants, and the baseline genomic diversity among gonococcal strains in Brazil, we conducted WGS on 548 isolates obtained in 2015-16 across all five macroregions in Brazil.METHODS: A total of 548 gonococcal isolates cultured across Brazil in 2015-16 were genome sequenced. AMR was determined using agar dilution and/or Etest. Genome sequences of isolates from Argentina (n = 158) and the 2016 WHO reference strains (n = 14) were included in the analysis.RESULTS: We found 302, 68 and 214 different NG-MAST, MLST and NG-STAR STs, respectively. The phylogenomic analysis identified one main antimicrobial-susceptible lineage and one AMR lineage, which was divided into two sublineages with different AMR profiles. Determination of NG-STAR networks of clonal complexes was shown as a new and valuable molecular epidemiological analysis. Several novel mosaic mtrD (and mtrR and mtrE) variants associated with azithromycin resistance were identified.CONCLUSIONS: We describe the first genomic baseline data to support the Brazilian GASP. The high prevalence of resistance to ciprofloxacin, tetracycline and benzylpenicillin, and the high number of isolates with mosaic penA and azithromycin resistance mutations, should prompt continued and strengthened AMR surveillance, including WGS, of N. gonorrhoeae in Brazil.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bazzo, Maria LuizaMolecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil
(författare)
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Golfetto, LisléiaMolecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil
(författare)
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Gaspar, Pamela CristinaDepartment of Diseases of Chronic Condition and Sexually Transmitted Infection, Secretariat of Health Surveillance, Ministry of Health of Brazil, Brasília, Brazil
(författare)
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Schörner, Marcos AndréMolecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil
(författare)
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Schwartz Benzaken, AdeleFoundation of Tropical Medicine of Amazonas, Manaus, Brazil
(författare)
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Ramos, Mauro CunhaBrazilian STD Society, Porto Alegre, Brazil
(författare)
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Ferreira, William AntunesAlfredo da Mata Foundation, Manaus, Brazil
(författare)
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Alonso Neto, José BoullosaDepartment of Diseases of Chronic Condition and Sexually Transmitted Infection, Secretariat of Health Surveillance, Ministry of Health of Brazil, Brasília, Brazil
(författare)
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Mendes Pereira, Gerson FernandoDepartment of Diseases of Chronic Condition and Sexually Transmitted Infection, Secretariat of Health Surveillance, Ministry of Health of Brazil, Brasília, Brazil
(författare)
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Unemo, Magnus,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine(Swepub:oru)muo
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Antimicrobial Chemotherapy: Oxford University Press75:11, s. 3163-31720305-74531460-2091
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Bazzo, Maria Lui ...
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