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Genomic Epidemiolog...
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Ariel Gianecini, RicardoInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005-2019
- Artikel/kapitelEngelska2021
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Centers for Disease Control and Prevention,2021
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LIBRIS-ID:oai:DiVA.org:oru-94928
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94928URI
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https://doi.org/10.3201/eid2709.204843DOI
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Språk:engelska
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Sammanfattning på:engelska
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Funding agencies:Genomics and Bioinformatics PlatformPrograma de Becas de Formacion en el Exterior en Ciencia y Tecnologia (Ciudad Autonoma de Buenos Aires)Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital (Örebro, Sweden)Instituto Nacional de Enfermedades Infecciosas-Administracion Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbran (Ciudad Autonoma de Buenos Aires, Argentina)
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Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015-2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005-2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015-November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2-4 mu g/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2-4 or >256 mu g/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina.
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Poklepovich, TomasInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
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Golparian, Daniel,1984-Örebro universitet,Institutionen för medicinska vetenskaper,World Health Organization Collaborating Centre for Gonorrhoea and Other STIs(Swepub:oru)degn
(författare)
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Cuenca, NoeliaInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
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Tuduri, EzequielInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
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Unemo, Magnus,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and Other STIs(Swepub:oru)muo
(författare)
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Campos, JosefinaInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
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Galarza, PatriciaInstituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina
(författare)
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Instituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, ArgentinaInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Emerging Infectious Diseases: Centers for Disease Control and Prevention27:9, s. 2369-23781080-60401080-6059
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