Sökning: onr:"swepub:oai:DiVA.org:oru-97722" >
Changes in plasma l...
Changes in plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with changes in plasma lipids : A longitudinal study over 10 years
-
- Dunder, Linda (författare)
- Uppsala universitet,Arbets- och miljömedicin
-
- Lind, P. Monica, 1957- (författare)
- Uppsala universitet,Arbets- och miljömedicin
-
- Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences,Örebro Univ, Sch Med Sci, Inflammatory Response & Infect Susceptibil Ctr, Örebro, Sweden.
-
visa fler...
-
- Stubleski, Jordan, 1990- (författare)
- School of Science and Technology, Örebro University, Örebro, Sweden; Wellington Laboratories Inc, Guelph, ON, Canada,Örebro Univ, Sch Sci & Technol, MTM, Örebro, Sweden.;Wellington Labs Inc, Guelph, ON, Canada.
-
- Kärrman, Anna, 1975- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Sch Sci & Technol, MTM, Örebro, Sweden.
-
- Lind, Lars (författare)
- Uppsala universitet,Kardiologi
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
-
Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 211
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Associations between per- and polyfluoroalkyl substances (PFAS), mainly PFOS and PFOA, and increased blood lipids have been reported primarily from cross-sectional studies. The aim of the present study was to investigate associations between multiple PFAS and blood lipids in a longitudinal fashion.METHODS: A total of 864 men and women aged 70 years and free from lipid medication were included from the PIVUS study, 614 and 404 of those were reinvestigated at age 75 and 80. At all three occasions, eight PFAS were measured in plasma using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were also measured in plasma at all three occasions. Mixed-effects linear regression models were used to examine the relationship between the changes in PFAS levels and changes in lipid levels.RESULTS: Changes in plasma levels of six out of the eight investigated PFAS were positively associated with changes in plasma lipids after adjustment for sex, change in body mass index (BMI), smoking, physical activity, statin use (age was the same in all subjects), and correction for multiple testing. For example, changes in perfluorodecanoic acid (PFDA) were positively associated with the changes in total cholesterol (β: 0.23, 95% confidence interval (CI): 0.14 to 0.32), triglycerides (β: 0.08, 95% CI: 0.04-0.12) and HDL-cholesterol (β: 0.08, 95% CI: 0.04-0.11).CONCLUSION: In this longitudinal study with three measurements over 10 years of both plasma PFAS and lipids, changes in six out of the eight investigated PFAS were positively associated with changes in plasma lipids, giving further support for a role of PFAS exposure in human lipid metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Dyslipidemia
- Epidemiology
- Longitudinal study
- PFAS
- Per- and polyfluoroalkyl substances
- Plasma lipids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas