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Risk of heart disea...
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Yang, HaominKarolinska Institutet
(författare)
Risk of heart disease following treatment for breast cancer - results from a population-based cohort study
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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eLife Sciences Publications Ltd,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-98819
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98819URI
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https://doi.org/10.7554/eLife.71562DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149268321URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:Natural Science Foundation of Fujian Province 2021J01721Startup Fund for High-level Talents of Fujian Medical University XRCZX2020007Startup Fund for Scientific Research, Fujian Medical University 2019QH1002Laboratory Construction Program of Fujian Medical University 1100160208University of Malaya Impact-Oriented Interdisciplinary Research Grant Programme IIRG006C-19HWBChina Scholarship Council
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Background: There is a rising concern about treatment-associated cardiotoxicities in breast cancer patients. This study aimed to determine the time- and treatment-specific incidence of arrhythmia, heart failure, and ischemic heart disease in women diagnosed with breast cancer.Methods: A register-based matched cohort study was conducted including 8015 breast cancer patients diagnosed from 2001 to 2008 in the Stockholm-Gotland region and followed up until 2017. Time-dependent risks of arrhythmia, heart failure, and ischemic heart disease in breast cancer patients were assessed using flexible parametric models as compared to matched controls from general population. Treatment-specific effects were estimated in breast cancer patients using Cox model.Results: Time-dependent analyses revealed long-term increased risks of arrhythmia and heart failure following breast cancer diagnosis. Hazard ratios (HRs) within the first year of diagnosis were 2.14 (95% CI = 1.63-2.81) for arrhythmia and 2.71 (95% CI = 1.70-4.33) for heart failure. HR more than 10 years following diagnosis was 1.42 (95% CI = 1.21-1.67) for arrhythmia and 1.28 (95% CI = 1.03-1.59) for heart failure. The risk for ischemic heart disease was significantly increased only during the first year after diagnosis (HR = 1.45, 95% CI = 1.03-2.04). Trastuzumab and anthracyclines were associated with increased risk of heart failure. Aromatase inhibitors, but not tamoxifen, were associated with risk of ischemic heart disease. No increased risk of heart disease was identified following locoregional radiotherapy.Conclusions: Administration of systemic adjuvant therapies appears to be associated with increased risks of heart disease. The risk estimates observed in this study may aid adjuvant therapy decision-making and patient counseling in oncology practices.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bhoo-Pathy, NirmalaCentre for Epidemiology and Evidence-Based Practice, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
(författare)
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Brand, Judith S.Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
(författare)
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Hedayati, ElhamDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Grassmann, FelixKarolinska Institutet
(författare)
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Zeng, ErweiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Bergh, JonasKarolinska Institutet
(författare)
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Bian, WeiweiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln
(författare)
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Hall, PerKarolinska Institutet
(författare)
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Czene, KamilaKarolinska Institutet
(författare)
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Karolinska InstitutetCentre for Epidemiology and Evidence-Based Practice, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
(creator_code:org_t)
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Ingår i:eLIFE: eLife Sciences Publications Ltd112050-084X
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Yang, Haomin
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Brand, Judith S.
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Hedayati, Elham
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Grassmann, Felix
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Zeng, Erwei
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Bergh, Jonas
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Bian, Weiwei
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Hall, Per
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Czene, Kamila
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