Acute resveratrol supplementation in coronary artery disease: towards patient stratification

Díaz, Miguel,HögskoleadjunktRöda Korsets Högskola,Hälsovetenskapliga institutionen,Manchester Metropolitan University, UK (författare)

Acute resveratrol supplementation in coronary artery disease : towards patient stratification

OBJECTIVE: Resveratrol (RV) is a polyphenol with antioxidant, anti-inflammatory and cardio-protective properties. Our objective was to investigate whether acute supplementation with high doses of RV would improve flow-mediated dilation (FMD) and oxygen consumption (VO2) kinetics in older coronary artery disease (CAD) patients.DESIGN: We employed a placebo-controlled, single-blind, crossover design in which ten participants (aged 66.6 ± 7.8 years) received either RV or placebo (330 mg, 3x day-1) during three consecutive days plus additional 330 mg in the morning of the fourth day with a seven-day wash-out period in-between. On the fourth day, FMD of the brachial artery and VO2 on-kinetics were determined. Results; RV improved FMD in patients who had undergone coronary artery bypass grafting (CABG; -1.4 vs. 5.0%; p = 0.004), but not in those who had undergone percutaneous coronary intervention (PCI; 4.2 vs. -0.2%; NS).CONCLUSION: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients.

Avila, AManchester Metropolitan University, UK / KU Leuven, Belgium (författare)
Degens, HManchester Metropolitan University, UK / Lithuanian Sports University, Lithuania (författare)
Coeckelberghs, EKU Leuven, Belgium (författare)
Vanhees, LKU Leuven, Belgium (författare)
Cornelissen, VKU Leuven, Belgium (författare)
Azzawi, MManchester Metropolitan University, UK (författare)
Röda Korsets HögskolaHälsovetenskapliga institutionen (creator_code:org_t)

Ingår i:Scandinavian Cardiovascular Journal: Taylor & Francis:1, s. 14-191401-74311651-2006

Av författaren/redakt...: Díaz, Miguel, Hö ...; Avila, A; Degens, H; Coeckelberghs, E; Vanhees, L; Cornelissen, V; visa fler...; Azzawi, M; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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