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Cyanoacetylation of...
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Slätt, JohnnySödertörns högskola,Institutionen för kemi, biologi, geografi och miljövetenskap,Karolinska Institutet
(författare)
Cyanoacetylation of indoles, pyrroles and amines, and synthetic uses of these products
Förlag, utgivningsår, omfång ...
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Stockholm :Karolinska instiutet,2005
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39 s.
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:sh-31953
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ISBN:9171402691
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10616/37961hdl
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https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-31953URI
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http://hdl.handle.net/10616/37961URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:dok swepub-publicationtype
Anmärkningar
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This thesis is based on an organic synthetic project aimed towards development of small molecules acting on the P2 receptor as well as development of synthetic methods to such molecules (primarily indoles and featuring isatogens in particular). The new methodology includes cyanoacetylation of indoles, pyrroles, amines, and enamines using cyanoacetic acid in acetic anhydride. The molecules obtained (e.g. 3-cyanoacetylindole) could be further functionalized by nitrosation followed by reduction. Cyanoacetylated anilines carrying an appropriate substituent (e.g NO2) could be cyclized to quinoxaline-N-oxides, a class of molecules which have been considered as analogues to isatogens. The molecule 2,2'-pyridylisatogen tosylate (PIT) is particularly interesting within this class because of its documented interaction with the P2 receptor.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bergman, Jan,ProfessorKarolinska Institutet
(preses)
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Erlinge, David,DocentLunds universitet
(preses)
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Hedner, Tomas,ProfessorGöteborgs universitet
(preses)
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Begtrup, MichaelDanish University of Pharmaceutical Sciences, Denmark
(opponent)
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Södertörns högskolaInstitutionen för kemi, biologi, geografi och miljövetenskap
(creator_code:org_t)
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Karolinska Institutet
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Karolinska Institutet
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