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Sökning: onr:"swepub:oai:DiVA.org:sh-42128" > Environmental risk ...

  • Kim, J. H.Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea (författare)

Environmental risk factors, protective factors, and peripheral biomarkers for ADHD : an umbrella review

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:sh-42128
  • https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-42128URI
  • https://doi.org/10.1016/S2215-0366(20)30312-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171725URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145114623URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Background: Many potential environmental risk factors, environmental protective factors, and peripheral biomarkers for ADHD have been investigated, but the consistency and magnitude of their effects are unclear. We aimed to systematically appraise the published evidence of association between potential risk factors, protective factors, or peripheral biomarkers, and ADHD. Methods: In this umbrella review of meta-analyses, we searched PubMed including MEDLINE, Embase, and the Cochrane Database of Systematic Reviews, from database inception to Oct 31, 2019, and screened the references of relevant articles. We included systematic reviews that provided meta-analyses of observational studies that examined associations of potential environmental risk factors, environmental protective factors, or peripheral biomarkers with diagnosis of ADHD. We included meta-analyses that used categorical ADHD diagnosis criteria according to DSM, hyperkinetic disorder according to ICD, or criteria that were less rigorous than DSM or ICD, such as self-report. We excluded articles that did not examine environmental risk factors, environmental protective factors, or peripheral biomarkers of ADHD; articles that did not include a meta-analysis; and articles that did not present enough data for re-analysis. We excluded non-human studies, primary studies, genetic studies, and conference abstracts. We calculated summary effect estimates (odds ratio [OR], relative risk [RR], weighted mean difference [WMD], Cohen's d, and Hedges' g), 95% CI, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases. We did analyses under credibility ceilings, and assessed the quality of the meta-analyses with AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews 2). This study is registered with PROSPERO, number CRD42019145032. Findings: We identified 1839 articles, of which 35 were eligible for inclusion. These 35 articles yielded 63 meta-analyses encompassing 40 environmental risk factors and environmental protective factors (median cases 16 850, median population 91 954) and 23 peripheral biomarkers (median cases 175, median controls 187). Evidence of association was convincing (class I) for maternal pre-pregnancy obesity (OR 1·63, 95% CI 1·49 to 1·77), childhood eczema (1·31, 1·20 to 1·44), hypertensive disorders during pregnancy (1·29, 1·22 to 1·36), pre-eclampsia (1·28, 1·21 to 1·35), and maternal acetaminophen exposure during pregnancy (RR 1·25, 95% CI 1·17 to 1·34). Evidence of association was highly suggestive (class II) for maternal smoking during pregnancy (OR 1·6, 95% CI 1·45 to 1·76), childhood asthma (1·51, 1·4 to 1·63), maternal pre-pregnancy overweight (1·28, 1·21 to 1·35), and serum vitamin D (WMD −6·93, 95% CI −9·34 to −4·51). Interpretation: Maternal pre-pregnancy obesity and overweight; pre-eclampsia, hypertension, acetaminophen exposure, and smoking during pregnancy; and childhood atopic diseases were strongly associated with ADHD. Previous familial studies suggest that maternal pre-pregnancy obesity, overweight, and smoking during pregnancy are confounded by familial or genetic factors, and further high-quality studies are therefore required to establish causality.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kim, J. Y.Yonsei University College of Medicine, Seoul, Republic of Korea,Yonsei Univ, South Korea (författare)
  • Lee, J.Yonsei University Wonju College of Medicine, Wonju, Republic of Korea,Yonsei Univ, South Korea (författare)
  • Jeong, G. H.Gyeongsang National University, Jinju, Republic of Korea,Gyeongsang Natl Univ, South Korea (författare)
  • Lee, E.Department of Psychiatry, Seoul, Republic of Korea,Yonsei Univ, South Korea (författare)
  • Lee, S.Department of Psychiatry, Seoul, Republic of Korea,Yonsei Univ, South Korea,Anglia Ruskin Univ, England (författare)
  • Lee, K. H.Department of Pediatrics, Seoul, Republic of Korea,Yonsei Univ, South Korea (författare)
  • Kronbichler, A.Medical University Innsbruck, Innsbruck, Austria,Med Univ Innsbruck, Austria (författare)
  • Stubbs, B.King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK; Anglia Ruskin University, Chelmsford, UK,Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Anglia Ruskin Univ, England (författare)
  • Solmi, M.King's College London, London, UK; University of Padova, Padova, Italy,Kings Coll London, England; Univ Padua, Italy; Univ Padua, Italy (författare)
  • Koyanagi, A.Universitat de Barcelona, Fundació Sant Joan de Deéu, Sant Boi de Llobregat, Barcelona, Spain,Univ Barcelona, Spain (författare)
  • Hong, S. H.Harvard T H Chan School of Public Health, Boston, MA, USA (författare)
  • Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71 (författare)
  • Jacob, L.Universitat de Barcelona, Fundació Sant Joan de Deéu, Sant Boi de Llobregat, Barcelona, Spain; University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France,Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France (författare)
  • Brunoni, A. R.University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Hospital Universitario, Departamento de Clínica Médica, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil,Ludwig Maximilian Univ Munich, Germany; Univ Sao Paulo, Brazil; Univ Sao Paulo, Brazil (författare)
  • Carvalho, A. F.Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada,Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada (författare)
  • Radua, J.Karolinska Institutet (författare)
  • Thompson, T.University of Greenwich, London, UK,Univ Greenwich, England (författare)
  • Smith, L.Anglia Ruskin University, Chelmsford, UK (författare)
  • Oh, H.University of Southern California, Los Angeles, CA, USA,Univ Southern Calif, CA 90007 USA (författare)
  • Yang, L.Alberta Health Services, Calgary, AB, Canada; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada,Alberta Hlth Serv, Canada; Univ Calgary, Canada; Univ Calgary, Canada (författare)
  • Grabovac, I.Medical University of Vienna, Vienna, Austria,Med Univ Vienna, Austria (författare)
  • Schuch, F.Federal University of Santa Maria, Santa Maria, Brazil,Univ Fed Santa Maria, Brazil (författare)
  • Fornaro, M.Federico II University, Naples, Italy,Univ Naples Federico II, Italy (författare)
  • Stickley, AndrewSödertörns högskola,SCOHOST (Stockholm Centre for Health and Social Change),National Centre of Neurology and Psychiatry, Tokyo, Japan,Natl Ctr Neurol & Psychiat, Japan; Sodertorn Univ, Sweden(Swepub:sh)SH99AWSY (författare)
  • Rais, T. B.University of Toledo Medical Center, Toledo, OH, USA,Univ Toledo, OH 43606 USA (författare)
  • de Pablo, G. S.King's College London, London, UK; Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERSAM, Madrid, Spain,Kings Coll London, England; Kings Coll London, England; Univ Complutense, Spain (författare)
  • Shin, J. I.Department of Pediatrics, Seoul, Republic of Korea,Yonsei Univ, South Korea (författare)
  • Fusar-Poli, P.King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK; University of Pavia, Pavia, Italy,Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy (författare)
  • Yonsei University College of Medicine, Seoul, Republic of KoreaYonsei Univ, South Korea (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Lancet psychiatry: Elsevier7:11, s. 955-9702215-03742215-0366

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