Sökning: onr:"swepub:oai:DiVA.org:su-115678" >
No difference in sm...
-
Dlugosz, AldonaKarolinska Institutet
(författare)
No difference in small bowel microbiota between patients with irritable bowel syndrome and healthy controls
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
-
2015-02-17
-
Springer Science and Business Media LLC,2015
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:su-115678
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115678URI
-
https://doi.org/10.1038/srep08508DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:130697489URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
AuthorCount:8;
-
Several studies have indicated that colonic microbiota may exhibit important differences between patients with irritable bowel syndrome (IBS) and healthy controls. Less is known about the microbiota of the small bowel. We used massive parallel sequencing to explore the composition of small bowel mucosa-associated microbiota in patients with IBS and healthy controls. We analysed capsule biopsies from the jejunum of 35 patients (26 females) with IBS aged 18-(36)-57 years and 16 healthy volunteers (11 females) aged 20-(32)-48 years. Sequences were analysed based on taxonomic classification. The phyla with the highest total abundance across all samples were: Firmicutes (43%), Proteobacteria (23%), Bacteroidetes (15%), Actinobacteria (9.3%) and Fusobacteria (7.0%). The most abundant genera were: Streptococcus (19%), Veillonella (13%), Prevotella (12%), Rothia (6.4%), Haemophilus (5.7%), Actinobacillus (5.5%), Escherichia (4.6%) and Fusobacterium (4.3%). We found no difference among major phyla or genera between patients with IBS and controls. We identified a cluster of samples in the small bowel microbiota dominated by Prevotella, which may represent a common enterotype of the upper small intestine. The remaining samples formed a gradient, dominated by Streptococcus at one end and Escherichia at the other.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Winckler, Björn
(författare)
-
Lundin, ElinStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)ellu0493
(författare)
-
Zakikhany, Katherina
(författare)
-
Sandström, GunnarKarolinska Institutet
(författare)
-
Ye, WeiminKarolinska Institutet
(författare)
-
Engstrand, LarsKarolinska Institutet
(författare)
-
Lindberg, GregerKarolinska Institutet
(författare)
-
Karolinska InstitutetInstitutionen för biokemi och biofysik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Scientific Reports: Springer Science and Business Media LLC52045-2322
Internetlänk
Hitta via bibliotek
Till lärosätets databas