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Predicting long-ter...
Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning
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- Månsson, Kristoffer N T (författare)
- Linköpings universitet,Psykologi,Filosofiska fakulteten,Internet, health and clinical psychology research group,Linköping University
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- Frick, Andreas (författare)
- Uppsala universitet,Institutionen för psykologi,Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.;Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, Dept Neuroimaging, London WC2R 2LS, England.,Uppsala Univ, Dept Psychol, Uppsala, Sweden,Uppsala University,Donders Institute, Radboud University
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- Boraxbekk, Carl-Johan, 1980- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Centrum för befolkningsstudier (CBS)
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Marquand, A. F. (författare)
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- Williams, S. C. R. (författare)
- Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, Dept Neuroimaging, London WC2R 2LS, England.,King's College London
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- Carlbring, Per (författare)
- Stockholms universitet,Psykologiska institutionen,Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.,Stockholm University
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- Andersson, Gerhard, 1966- (författare)
- Karolinska Institutet,Linköpings universitet,Psykologi,Filosofiska fakulteten,Internet, health and clinical psychology research group,Linköping University
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Dept Psychol, Uppsala, Sweden,Uppsala University
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(creator_code:org_t)
- 2015-03-17
- 2015
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 5
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cognitive behavior therapy (CBT) is an effective treatment for social anxiety disorder (SAD), but many patients do not respond sufficiently and a substantial proportion relapse after treatment has ended. Predicting an individual’s long-term clinical response therefore remains an important challenge. This study aimed at assessing neural predictors of long-term treatment outcome in participants with SAD 1 year after completion of Internet-delivered CBT (iCBT). Twenty-six participants diagnosed with SAD underwent iCBT including attention bias modification for a total of 13 weeks. Support vector machines (SVMs), a supervised pattern recognition method allowing predictions at the individual level, were trained to separate long-term treatment responders from nonresponders based on blood oxygen level-dependent (BOLD) responses to self-referential criticism. The Clinical Global Impression-Improvement scale was the main instrument to determine treatment response at the 1-year follow-up. Results showed that the proportion of long-term responders was 52%(12/23). From multivariate BOLD responses in the dorsal anterior cingulate cortex (dACC) together with the amygdala, we were able to predict long-term response rate of iCBT with an accuracy of 92% (confidence interval 95% 73.2–97.6). This activation pattern was, however, not predictive of improvement in the continuous Liebowitz Social Anxiety Scale—Self-report version. Follow-up psychophysiological interaction analyses revealed that lower dACC–amygdala coupling was associated with better long-term treatment response. Thus, BOLD response patterns in the fear-expressing dACC–amygdala regions were highly predictive of long-term treatment outcome of iCBT, and the initial coupling between these regions differentiated long-term responders from nonresponders. The SVM-neuroimaging approach could be of particular clinical value as it allows for accurate prediction of treatment outcome at the level of the individual.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)
Nyckelord
- internet-delivered therapy
- CBT
- social anxiety disorder
- fMRI
- vector machine learning
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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