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FältnamnIndikatorerMetadata
00011199naa a2201525 4500
001oai:DiVA.org:su-211734
003SwePub
008221125s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-101500
009oai:prod.swepub.kib.ki.se:151128845
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2117342 URI
0247 a https://doi.org/10.1016/j.envres.2022.1143852 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1015002 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1511288452 URI
040 a (SwePub)sud (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hvidtfeldt, Ulla Arthuru Danish Cancer Society Research Center, Copenhagen, Denmark4 aut
2451 0a Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution :b a Study in Europe (ELAPSE)
264 1b Academic Press Inc.c 2022
338 a print2 rdacarrier
520 a BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985–2005) to 2011–2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5–95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8–39.2), 15.3 μg/m3 (8.6–19.2), 1.6 10−5 m−1 (0.7–2.1), and 87.0 μg/m3 (70.3–97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10−5 m−1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a air Pollution
653 a Kidney cancer incidence
653 a Nitrogen dioxide
653 a Ozone
653 a Particulate matter
653 a PM elemental Components
653 a black carbon
653 a copper
653 a iron
653 a nickel
653 a potassium
653 a silicon
653 a sulfur
653 a trace metal
653 a vanadium
653 a zinc
653 a carbon
653 a carcinogen
653 a ambient air
653 a atmospheric pollution
653 a cancer
653 a confidence interval
653 a DNA
653 a pollution exposure
653 a adult
653 a Article
653 a body mass
653 a cancer incidence
653 a cancer registry
653 a cohort analysis
653 a controlled study
653 a European
653 a female
653 a follow up
653 a human
653 a ICD-9
653 a kidney cancer
653 a kidney parenchyma
653 a long term exposure
653 a major clinical study
653 a male
653 a obesity
653 a PM2.5 exposure
653 a proportional hazards model
653 a residential area
653 a season
653 a adverse event
653 a air pollutant
653 a analysis
653 a environmental exposure
653 a Europe
653 a exhaust gas
653 a kidney
653 a kidney tumor
653 a soot
653 a toxicity
653 a Air Pollutants
653 a Carcinogens
653 a Humans
653 a Kidney Neoplasms
653 a Vehicle Emissions
7001 a Taj, Tahir,d 1982-u Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Danish Cancer Society Research Center, Copenhagen, Denmark; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden,Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut0 (Swepub:oru)ttj
7001 a Chen, Jieu Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands4 aut
7001 a Rodopoulou, Sophiau Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece4 aut
7001 a Strak, Macieju Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands4 aut
7001 a de Hoogh, Keesu Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland4 aut
7001 a Andersen, Zorana J.u Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Bellander, Tomu Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden4 aut
7001 a Brandt, Jørgenu Department of Environmental Science, Aarhus University, Roskilde, Denmark; Climate – Interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark4 aut
7001 a Fecht, Danielau MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK4 aut
7001 a Forastiere, Francescou Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College, London, UK4 aut
7001 a Gulliver, Johnu MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, UK4 aut
7001 a Hertel, Oleu Departments of Ecoscience, Aarhus University, Roskilde, Denmark4 aut
7001 a Hoffmann, Barbarau Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany4 aut
7001 a Jørgensen, Jeanette T.4 aut
7001 a Katsouyanni, Kleau Karolinska Institutet4 aut
7001 a Ketzel, Matthiasu Department of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford GU2 7XH, United Kingdom4 aut
7001 a Lager, Antonu Karolinska Institutet4 aut
7001 a Leander, Karinu Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Ljungman, Petteru Karolinska Institutet4 aut
7001 a Magnusson, Patrik K. E.4 aut
7001 a Nagel, Gabrieleu Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany4 aut
7001 a Pershagen, Göranu Karolinska Institutet4 aut
7001 a Rizzuto, Deborau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden4 aut
7001 a Samoli, Evangeliau Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece4 aut
7001 a So, Rinau Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Stafoggia, Massimou i Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut
7001 a Vermeulen, Roelu Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands4 aut
7001 a Weinmayr, Gudrunu Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany4 aut
7001 a Wolf, Kathrinu Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany4 aut
7001 a Zhang, Jiaweiu Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Zitt, Emanuelu Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria4 aut
7001 a Brunekreef, Bertu Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands4 aut
7001 a Hoek, Gerardu Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands4 aut
7001 a Raaschou-Nielsen, Oleu Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Roskilde, Denmark4 aut
7102 a Danish Cancer Society Research Center, Copenhagen, Denmarkb Institutionen för hälsovetenskaper4 org
7730 t Environmental Researchd : Academic Press Inc.g 215q 215x 0013-9351x 1096-0953
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-211734
8564 8u https://doi.org/10.1016/j.envres.2022.114385
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101500
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151128845

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