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Elevated Peripheral...
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Johansson, CatharinaKarolinska Institutet
(författare)
Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-04-02
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S. Karger AG,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-60077
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-60077URI
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https://doi.org/10.1159/000210380DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118788912URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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authorCount :7
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Background: Atopic eczema is a chronic inflammatory skin disease in which several subgroups of cases can be identified. Atopy patch testing (APT) reveals allergen sensitization also in atopic eczema patients devoid of detectable allergen-specific IgE, suggesting the importance of factors other than IgE in the reaction. Here we investigate the relationship between APT reactions and allergen-specific peripheral IgE and T cell reactivity in atopic eczema patients. Methods: Adult patients with atopic eczema (n = 64) and healthy controls (n = 24) were analyzed for reactivity to Malassezia sympodialis extract by APT, measurement of specific plasma IgE and in vitro determination of the frequency of allergen-reactive peripheral blood mononuclear cells producing interleukin-4 and interleukin-5 using the ELISpot method. Results: When combining the results of the APT, IgE measurements and the ELISpot analyses, reactivity to M. sympodialis was found in a majority of the atopic eczema patients (69%), whereas the healthy controls were negative throughout. T cell reactivity to M. sympodialis, manifested by production of both interleukins 4 and 5, was highly predictive for a positive APT reaction and displayed a strongly positive correlation with the APT score. In contrast, the allergen-specific IgE levels did not predict the APT outcome, and no correlation could be found between the IgE levels and the APT score. Conclusion: Peripheral allergen-specific T helper 2 cell-mediated reactivity appears to be required for a positive APT reaction to M. sympodialis. The diagnostic potential of measuring peripheral allergen-specific T cell responses should be considered in atopic eczema.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ahlborg, NiklasStockholms universitet,Avdelningen för immunologi
(författare)
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Andersson, AnnaKarolinska Institutet
(författare)
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Lundeberg, Lena
(författare)
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Karlsson, Maria A.
(författare)
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Scheynius, Annika
(författare)
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Linder, Maria TengvallKarolinska Institutet
(författare)
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Karolinska InstitutetAvdelningen för immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Archives of Allergy and Immunology: S. Karger AG150:1, s. 51-581018-24381423-0097
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