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Radiobiological fra...
Radiobiological framework for the evaluation of stereotactic radiosurgery plans for invasive brain tumours
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- Sandström, Helena (författare)
- Stockholms universitet,Fysikum,Medical Radiation Physics, Stockholm University and Karolinska Institutet, 171 76 Stockholm, Sweden,Stockholm University and Karolinska Institutet
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- Dasu, Alexandru (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Radiofysikavdelningen US,Department of Radiation Physics UHL, County Council of Östergötland, Linköping University, 581 85 Linköping, Sweden
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- Toma-Dasu, Iuliana (författare)
- Karolinska Institutet,Stockholms universitet,Fysikum,Medical Radiation Physics, Stockholm University and Karolinska Institutet, 171 76 Stockholm, Sweden,Stockholm University and Karolinska Institutet
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(creator_code:org_t)
- Hindawi Limited, 2013
- 2013
- Engelska.
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Ingår i: ISRN Oncology. - : Hindawi Limited. - 2090-5661 .- 2090-567X. ; 2013
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Abstract
Ämnesord
Stäng
- This study presents a radiobiological formalism for the evaluation of the treatment plans with respect to the probability of controlling tumours treated with SRS accounting for possible infiltrations of malignant cells beyond the margins of the delineated target.Treatments plans devised for three anaplastic astrocytoma cases were assumed for this study representing cases with different difficulties for target coverage. Several scenarios were considered regarding the infiltration patterns. Tumour response was described in terms of tumour control probability (TCP) assuming a Poisson model taking into account the initial number of clonogenic cells and the cell survival.The results showed the strong impact of the pattern of infiltration of tumour clonogens outside the delineated target on the outcome of the treatment. The treatment plan has to take into account the existence of the possible microscopic disease around the visible lesion otherwise the high gradients around the target effectively prevent the sterilisation of the microscopic spread leading to low probability of control, in spite of the high dose delivered to the target.From this perspective, the proposed framework offers a further criterion for the evaluation of stereotactic radiosurgery plans taking into account the possible infiltration of tumour cells around the visible target.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Radiobiology
- Stereotactic Radiosurgery
- Target delineation
- Astrocytoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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