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Physical activity a...
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Grotta, Alessandra
(författare)
Physical activity and body mass index as predictors of prostate cancer risk
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015-01-04
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Springer Science and Business Media LLC,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-121211
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-121211URI
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https://doi.org/10.1007/s00345-014-1464-5DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365947URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132076921URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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PURPOSE: Physical activity and body mass index (BMI) are involved in prostate cancer etiology; possible biologic mechanisms include their effects on hormonal levels. Our aim was to investigate the relationship between physical activity, obesity, and prostate cancer.METHODS: We followed a cohort of 13,109 Swedish men for 13 years and investigated the association of self-reported physical activity and BMI at baseline with prostate cancer incidence. We further analyzed whether BMI could modulate effects of physical activity. Occupational, recreational, and total physical activity were analyzed in relation to overall, localized, and advanced prostate cancer.RESULTS: During the study follow-up, we observed a total of 904 cases of prostate cancer (429 localized, 407 advanced, and 68 unclassified). High levels of occupational physical activity were associated with a nonsignificantly decreased risk of overall (HR 0.81, 95 % CI 0.61-1.07), localized (HR 0.75, 95 % CI 0.51-1.12), and advanced (HR 0.85, 95 % CI 0.55-1.31) prostate cancer. We found no association between high BMI and risk of prostate cancer incidence: We observed, however, a significant interaction between BMI and leisure physical activity.CONCLUSION: No association was confirmed between total physical activity and localized or advanced prostate cancer. The highest, relative to the lowest, level of occupational physical activity tended to be linked to a lower risk of prostate cancer, with a suggested dose-response relationship. We found no association between high BMI and risk of prostate cancer incidence; however, our analyses suggested an interaction between BMI and physical activity during recreational time that merits further investigation in future studies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bottai, MatteoKarolinska Institutet
(författare)
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Adami, Hans-OlovKarolinska Institutet
(författare)
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Adams, Swann Arp
(författare)
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Akre, OlofKarolinska Institutet
(författare)
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Blair, Steven Noel
(författare)
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Mariosa, DanielaKarolinska Institutet
(författare)
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Nyrén, Olof
(författare)
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Ye, WeiminKarolinska Institutet
(författare)
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Stattin, PärUmeå universitet,Urologi och andrologi,Surgery and Perioperative Sciences, Urology and AndrologyUmeå University HospitalUmeåSweden(Swepub:uu)parst892
(författare)
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Bellocco, RinoKarolinska Institutet
(författare)
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Trolle Lagerros, YlvaKarolinska Institutet
(författare)
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Karolinska InstitutetUrologi och andrologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:World journal of urology: Springer Science and Business Media LLC33:10, s. 1495-15020724-49831433-8726
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Grotta, Alessand ...
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Bottai, Matteo
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Adami, Hans-Olov
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Adams, Swann Arp
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Akre, Olof
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Blair, Steven No ...
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visa fler...
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Mariosa, Daniela
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Nyrén, Olof
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Ye, Weimin
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Stattin, Pär
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Bellocco, Rino
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Trolle Lagerros, ...
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visa färre...
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och Klinisk medicin
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och Urologi och njur ...
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MEDICIN OCH HÄLS ...
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet