Sökning: onr:"swepub:oai:DiVA.org:umu-126626" > Prediagnostic selen...
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000 | 05404naa a2200937 4500 | |
001 | oai:DiVA.org:umu-126626 | |
003 | SwePub | |
008 | 161012s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134044230 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1266262 URI |
024 | 7 | a https://doi.org/10.3945/ajcn.116.1316722 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1340442302 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hughes, David J.4 aut |
245 | 1 0 | a Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort |
264 | 1 | b Elsevier BV,c 2016 |
338 | a print2 rdacarrier | |
520 | a Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract.Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression.Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend <= 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63).Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a hepatocellular carcinoma | |
653 | a selenium | |
653 | a selenoprotein P | |
653 | a prospective cohort | |
653 | a liver cancer | |
653 | a hepatobiliary ncer | |
653 | a selenium status | |
700 | 1 | a Duarte-Salles, Talita4 aut |
700 | 1 | a Hybsier, Sandra4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Stepien, Magdalena4 aut |
700 | 1 | a Aleksandrova, Krasimira4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Affret, Aurelie4 aut |
700 | 1 | a Fagherazzi, Guy4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Katzke, Verena4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Bamia, Christina4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Peppa, Eleni4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Bueno-de-Mesquita, Hendrik Bastiaan4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a Engeset, Dagrun4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Lasheras, Cristina4 aut |
700 | 1 | a Agudo, Antonio4 aut |
700 | 1 | a Sanchez, Maria-Jose4 aut |
700 | 1 | a Navarro, Carmen4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Hemmingsson, Oskaru Umeå universitet,Kirurgi4 aut0 (Swepub:umu)osrhen96 |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Bradbury, Kathryn E.4 aut |
700 | 1 | a Cross, Amanda J.4 aut |
700 | 1 | a Gunter, Marc4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Schomburg, Lutz4 aut |
700 | 1 | a Jenab, Mazda4 aut |
710 | 2 | a Karolinska Institutetb Kirurgi4 org |
773 | 0 | t American Journal of Clinical Nutritiond : Elsevier BVg 104:2, s. 406-414q 104:2<406-414x 0002-9165x 1938-3207 |
856 | 4 | u https://academic.oup.com/ajcn/article-pdf/104/2/406/23773379/ajcn131672.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126626 |
856 | 4 8 | u https://doi.org/10.3945/ajcn.116.131672 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134044230 |
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