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Sentinel node detec...
Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report
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- Rosenblatt, Robert (författare)
- Umeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden
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- Johansson, Markus (författare)
- Sundsvall Hosp, Dept Urol, Sundsvall, Sweden
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- Alamdari, Farhood (författare)
- Vastmanland Hosp, Dept Urol, Vasteras, Sweden
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- Sidiki, Alexander (författare)
- Lanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden
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- Holmström, Benny (författare)
- Uppsala universitet,Urologkirurgi
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- Hansson, Johan, 1964- (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg
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- Vasko, Janos (författare)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden
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- Marits, Per (författare)
- Karolinska Institutet
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- Gabrielsson, Susanne (författare)
- Karolinska Institutet
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- Riklund, Katrine (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden
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- Winqvist, Ola (författare)
- Karolinska Institutet
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- Sherif, Amir (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden
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(creator_code:org_t)
- 2016-10-13
- 2017
- Engelska.
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Ingår i: World journal of urology. - : Springer Science and Business Media LLC. - 0724-4983 .- 1433-8726. ; 35:6, s. 921-927
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Abstract
Ämnesord
Stäng
- PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Urinary bladder neoplasms
- Neoadjuvant therapy
- Cisplatin
- Sentinel lymph node biopsy
- Cystectomy
- Immunotherapy
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- ref (ämneskategori)
- art (ämneskategori)
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Rosenblatt, Robe ...
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Johansson, Marku ...
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Alamdari, Farhoo ...
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Sidiki, Alexande ...
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Holmström, Benny
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Hansson, Johan, ...
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Vasko, Janos
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Marits, Per
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Gabrielsson, Sus ...
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Riklund, Katrine
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Winqvist, Ola
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Sherif, Amir
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Umeå universitet
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