Amino acid naphthylamidase isozymes in human cells grown in vitro: Hormonal regulation and isozyme differentiation in cancer cells and normal cells

Amino acid naphthylamidase isozymes in human cells grown in vitro : Hormonal regulation and isozyme differentiation in cancer cells and normal cells

The elucidation of regulatory mechanisms in higher organisms represents a front line problem in biochemical genetics. In Man the only material available for experimental studies of regulatory mechanisms is cells cultured in vitro. Enzymes which are differentiated into isozymes may have a complexgenetic background involving the action of more than one gene locus. The study of isozyme systems in cultured cells has developed into a valuable tool of increasing importance for the understanding of the genetic regulatorymechanisms in normal cells as well as in cancer cells.The purposes of this investigation were:1. to elucidate the isozyme differentiation of amino acid naphthylamidasein cultured human cancer cells and normal cells.2. to study the regulatory effects of steroid hormones especially hydrocortisoneon the levels of the different isozymes.

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