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Sökning: onr:"swepub:oai:DiVA.org:umu-141998" > A combination of pl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008430naa a2200913 4500
001oai:DiVA.org:umu-141998
003SwePub
008171121s2017 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e121d8bd-6565-4e17-b9ed-14776c97f608
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1419982 URI
0247 a https://doi.org/10.1371/journal.pmed.10024092 DOI
0247 a https://lup.lub.lu.se/record/e121d8bd-6565-4e17-b9ed-14776c97f6082 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Imamura, Fumiakiu University of Cambridge4 aut
2451 0a A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes :b The EPIC-InterAct case-cohort study
264 c 2017-10-11
264 1b Public Library Science,c 2017
338 a electronic2 rdacarrier
520 a Background Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.Methods and findings We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested casecohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of.-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding.Conclusions A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Sharp, Stephen J.u University of Cambridge4 aut
7001 a Koulman, Albertu MRC Human Nutrition Research,University of Cambridge4 aut
7001 a Schulze, Matthias B.u German Institute of Human Nutrition,University of Paris-Saclay4 aut
7001 a Kröger, Janineu German Institute of Human Nutrition4 aut
7001 a Griffin, Julian L.u University of Cambridge4 aut
7001 a Huerta, José M.u CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Guevara, Marcelau CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Sluijs, Ivonneu University Medical Center Utrecht4 aut
7001 a Agudo, Antoniou Catalan Institute of Oncology4 aut
7001 a Ardanaz, Evau CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Balkau, Beverley4 aut
7001 a Boeing, Heineru German Institute of Human Nutrition4 aut
7001 a Chajes, Veroniqueu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Dahm, Christina C.u Aarhus University4 aut
7001 a Dow, Courtneyu Institut Gustave Roussy,University of Paris-Saclay4 aut
7001 a Fagherazzi, Guyu University of Paris-Saclay,Institut Gustave Roussy4 aut
7001 a Feskens, Edith J. M.u Wageningen University4 aut
7001 a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Allmänmedicin,Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-plf
7001 a Gavrila, Dianau CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council,Hospital Virgen de la Arrixaca4 aut
7001 a Gunter, Marcu Aarhus University4 aut
7001 a Kaaks, Rudolfu German Cancer Research Centre4 aut
7001 a Key, Timothy J.u University of Oxford4 aut
7001 a Khaw, Kay-Teeu University of Cambridge4 aut
7001 a Kuehn, Tilmanu German Cancer Research Centre4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome
7001 a Molina-Portillo, Elenau University of Granada,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Nilsson, Peter M.u University of Cambridge4 aut0 (Swepub:lu)medf-pni
7001 a Olsen, Anjau Danish Cancer Society4 aut
7001 a Overvad, Kimu Aarhus University,Aarhus University Hospital4 aut
7001 a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut
7001 a Panico, Salvatoreu University of Naples Federico II4 aut
7001 a Rolandsson, Olovu Umeå University,Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005
7001 a Sieri, Sabinau Istituto Nazionale dei Tumori4 aut
7001 a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin4 aut
7001 a Slimani, Nadiau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Spijkerman, Annemieke M. W.u National Institute for Public Health and the Environment (RIVM)4 aut
7001 a Tjønneland, Anneu Danish Cancer Society4 aut
7001 a Tumino, Rosariou Civic and M.P Arezzo Hospital4 aut
7001 a van der Schouw, Yvonne T.u University Medical Center Utrecht4 aut
7001 a Langenberg, Claudiau University of Cambridge4 aut
7001 a Riboli, Eliou Imperial College London4 aut
7001 a Forouhi, Nita G.u University of Cambridge4 aut
7001 a Wareham, Nick J.u University of Cambridge4 aut
7102 a University of Cambridgeb MRC Human Nutrition Research4 org
7730 t PLoS Medicined : Public Library Scienceg 14:10q 14:10x 1549-1277x 1549-1676
8564 u https://doi.org/10.1371/journal.pmed.1002409y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1159046/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002409&type=printable
8564 u http://dx.doi.org/10.1371/journal.pmed.1002409x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141998
8564 8u https://doi.org/10.1371/journal.pmed.1002409
8564 8u https://lup.lub.lu.se/record/e121d8bd-6565-4e17-b9ed-14776c97f608

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