Sökning: onr:"swepub:oai:DiVA.org:umu-143680" >
Health Status Persp...
-
Pinto, SusanaUmeå universitet,Klinisk neurovetenskap,Institute of Physiology, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal
(författare)
Health Status Perspectives in Amyotrophic Lateral Sclerosis
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
-
2017-10-31
-
S. Karger,2017
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-143680
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143680URI
-
https://doi.org/10.1159/000480638DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background/Aims: The global perception of the health status (HS) of amyotrophic lateral sclerosis (ALS) patients before the initial diagnosis has not been addressed previously. Methods: We recorded the following at the first visit, before diagnostic information: (1) visual analog scale (VAS) of the EQ-5D; (2) the revised ALS functional rating scale (ALSFRSR), bulbar (ALSFRSb), upper limb (ALSFRSul), lower limb (ALSFRSll), and respiratory (RofALSFRS-R) subscores; and (3) forced and slow vital capacities. Correlations were tested by the Pearson correlation test. Variables were compared between groups defined by the VAS median value. p < 0.05 was considered significant. Results: Of the 156 patients included in the study (91 spinal-onset, 49 bulbar-onset, 16 axial/respiratory- onset; 95 men; mean onset age 63.9 +/- 13 years; mean disease duration 18.4 +/- 26.5 months), HS VAS was significantly lower in spinal-onset patients (p = 0.047), and particularly in spinal-onset women (p = 0.027). Disease duration had no influence. HS VAS was moderately correlated with ALS-FRS, ALSFRSul and ALSFRSll (0.4 < r < 0.5, p < 0.01), weakly correlated with RofALSFRS-R in the whole population (r = 0.171, p < 0.05), and not correlated with ALSFRSb or the respiratory tests. ALSFRSb was similar between groups defined by the HS VAS median value, but the other scores were significantly lower for poorer HS values. Conclusion: HS before diagnosis is mostly dependent on the perception of upper and lower limb function. A tool tailored to evaluate HS in bulbar-onset patients should be developed.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
de Carvalho, Mamede
(författare)
-
Umeå universitetKlinisk neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Neurodegenerative Diseases: S. Karger17:6, s. 323-3291660-28541660-2862
Internetlänk
Hitta via bibliotek
Till lärosätets databas