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Epigenetic changes ...
Epigenetic changes in the CRH gene are related to severity of suicide attempt and a general psychiatric risk score in adolescents
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- Jokinen, Jussi (författare)
- Karolinska Institutet,Umeå universitet,Psykiatri,Department of Clinical Neuroscience/Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden; Umeå Univ, Dept Clin Sci Psychiat, Umeå, Sweden
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- Boström, Adrian (författare)
- Uppsala universitet,Funktionell farmakologi
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- Dadfar, Ali (författare)
- Uppsala universitet,Funktionell farmakologi,Umeå Univ, Dept Clin Sci Psychiat, Umeå, Sweden
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- Ciuculete, Diana-Maria (författare)
- Uppsala universitet,Funktionell farmakologi
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- Chatzittofis, Andreas (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden; Univ Cyprus, Sch Med, Nicosia, Cyprus
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- Asberg, Marie (författare)
- Karolinska Institutet
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 27, s. 123-133
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was measured in whole blood using the Illumina Infinium Methylation EPIC BeadChip. Subjects were stratified into high-risk and low-risk groups based on the severity of the suicidal behavior. We included CpG sites located within 2000 basepairs away from transcriptional start site of the following HPA-axis coupled genes: corticotropin releasing hormone (CRH), corticotropin releasing hormone binding protein (CRHBP), corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), FK506-binding protein 51 (FKBP5) and the glucocorticoid receptor (NR3C1). Themethylation state of two corticotropin releasing hormone (CRH)-associated CpG siteswere significantly hypomethylated in the high-risk group of suicide attempters (n=31) (cg19035496 and cg23409074) (p < 0.001). Adolescent cohort 1 and 2 consisted of 129 and 93 subjects, respectively, and were stratified by the in silico generated DAWBA measurements of a general psychiatric risk score into high-risk group (>similar to 50% risk) or controls. In adolescent cohort 2, cg19035496 was hypermethylated in subjects with a high general psychiatric risk score. Our results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Suicide
- Suicide attempt
- HPA axis
- CRH gene
- Epigenetics
- Methylation
- Adolescent depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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