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Long-Term Effective...
Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men A Randomized Trial
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Holme, Oyvind (författare)
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Loberg, Magnus (författare)
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Kalager, Mette (författare)
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Bretthauer, Michael (författare)
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Hernan, Miguel A. (författare)
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Aas, Eline (författare)
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Eide, Tor J. (författare)
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Skovlund, Eva (författare)
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Lekven, Jon (författare)
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- Schneede, Jørn (författare)
- Umeå universitet,Farmakologi
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Tveit, Kjell Magne (författare)
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Vatn, Morten (författare)
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Ursin, Giske (författare)
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Hoff, Geir (författare)
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(creator_code:org_t)
- American College of Physicians, 2018
- 2018
- Engelska.
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Ingår i: Annals of Internal Medicine. - : American College of Physicians. - 0003-4819 .- 1539-3704. ; 168:11, s. 775-782
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
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- Background: The long-term effects of sigmoidoscopy screening on colorectal cancer (CRC) incidence and mortality in women and men are unclear.Objective: To determine the effectiveness of flexible sigmoidoscopy screening after 15 years of follow-up in women and men.Design: Randomized controlled trial. (ClinicalTrials.gov: NCT00119912)Setting: Oslo and Telemark County, Norway. Participants: Adults aged 50 to 64 years at baseline without prior CRC.Intervention: Screening (between 1999 and 2001) with flexible sigmoidoscopy with and without additional fecal blood testing versus no screening. Participants with positive screening results were offered colonoscopy.Measurements: Age-adjusted CRC incidence and mortality stratified by sex.Results: Of 98 678 persons, 20 552 were randomly assigned to screening and 78 126 to no screening. Adherence rates were 64.7% in women and 61.4% in men. Median follow-up was 14.8 years. The absolute risks for CRC in women were 1.86% in the screening group and 2.05% in the control group (risk difference, -0.19 percentage point [95% CI, -0.49 to 0.11 percentage point]; HR, 0.92 [CI, 0.79 to 1.07]). In men, the corresponding risks were 1.72% and 2.50%, respectively (risk difference, -0.78 percentage point [CI, -1.08 to -0.48 percentage points]; hazard ratio [HR], 0.66 [CI, 0.57 to 0.78]) (P for heterogeneity = 0.004). The absolute risks for death from CRC in women were 0.60% in the screening group and 0.59% in the control group (risk difference, 0.01 percentage point [CI, -0.16 to 0.18 percentage point]; HR, 1.01 [CI, 0.77 to 1.33]). The corresponding risks for death from CRC in men were 0.49% and 0.81%, respectively (risk difference, -0.33 percentage point [CI, -0.49 to -0.16 percentage point]; HR, 0.63 [CI, 0.47 to 0.83]) (P for heterogeneity = 0.014).Limitation: Follow-up through national registries.Conclusion: Offering sigmoidoscopy screening in Norway reduced CRC incidence and mortality in men but had little or no effect in women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Holme, Oyvind
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Loberg, Magnus
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Kalager, Mette
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Bretthauer, Mich ...
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Hernan, Miguel A ...
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Aas, Eline
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visa fler...
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Eide, Tor J.
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Skovlund, Eva
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Lekven, Jon
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Schneede, Jørn
-
Tveit, Kjell Mag ...
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Vatn, Morten
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Ursin, Giske
-
Hoff, Geir
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visa färre...
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