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FältnamnIndikatorerMetadata
00006799naa a2200745 4500
001oai:DiVA.org:umu-164032
003SwePub
008191016s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-395731
009oai:lup.lub.lu.se:27323e96-f084-4c65-9ed2-68c4c5907b08
009oai:DiVA.org:liu-160986
009oai:prod.swepub.kib.ki.se:141917157
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1640322 URI
0247 a https://doi.org/10.1111/joim.129412 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3957312 URI
0247 a https://lup.lub.lu.se/record/27323e96-f084-4c65-9ed2-68c4c5907b082 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1609862 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1419171572 URI
040 a (SwePub)umud (SwePub)uud (SwePub)lud (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mofors, J.u Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden4 aut
2451 0a Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome
264 c 2019-06-17
264 1b John Wiley & Sons,c 2019
338 a electronic2 rdacarrier
500 a Funding Agencies|Heart-Lung FoundationSwedish Heart-Lung Foundation; Karolinska InstituteKarolinska Institutet; Stockholm County CouncilStockholm County Council; Swedish Research CouncilSwedish Research Council; Swedish Rheumatism Association; King Gustaf the V:th 80-year Foundation
520 a Background: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.Methods: A cohort of patients with primary Sjögren's syndrome in Sweden (n = 960) and matched controls from the general population (n = 9035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.Results: During a median follow‐up of 9.5 years, the overall hazard ratio (HR) was 1.6 (95% CI 1.2–2.1) for myocardial infarction, 1.2 (95% CI 0.9–1.7) for cerebral infarction and 2.1 (95% CI 1.6–2.9) for venous thromboembolism. Patients positive for both Ro/SSA and La/SSB autoantibodies had a substantially higher risk of cerebral infarction (HR 1.7, 95% CI 1.0–2.9) and venous thromboembolism (HR 3.1, 95% CI 1.9–4.8) than the general population. These risks were not significantly increased in Ro/SSA‐ and La/SSB‐negative patients. Among autoantibody‐positive patients, the highest HR of cerebral infarction was seen after ≥10 years disease duration (HR 2.8, 95% CI 1.4–5.4), while the HR for venous thromboembolism was highest 0–5 years after disease diagnosis (HR 4.7, 95% CI 2.3–9.3) and remained high throughout disease duration.Conclusions: Primary Sjögren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a autoantibodies
653 a cardiovascular disease
653 a La
653 a SSB
653 a Primary Sjögren's syndrome
653 a Ro
653 a SSA
7001 a Holmqvist, M.u Karolinska Institutet4 aut
7001 a Westermark, L.u Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden4 aut
7001 a Björk, A.u Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden4 aut
7001 a Kvarnström, M.u Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden4 aut
7001 a Forsblad-d'Elia, Helenau Umeå University,Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umea, Sweden4 aut0 (Swepub:umu)hefo0034
7001 a Bucher, S. Magnussonu Örebro University,Orebro Univ, Sweden4 aut
7001 a Eriksson, Peru Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)perer22
7001 a Theander, Elkeu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)medf-eth
7001 a Mandl, Thomasu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)medf-tma
7001 a Wahren-Herlenius, M.u Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden4 aut
7001 a Nordmark, Gunnelu Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden4 aut0 (Swepub:uu)gunnnord
7102 a Karolinska Instituteb Karolinska Univ Hosp, Sweden4 org
7730 t Journal of Internal Medicined : John Wiley & Sonsg 286:4, s. 458-468q 286:4<458-468x 0954-6820x 1365-2796
8564 u https://doi.org/10.1111/joim.12941y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1361585/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12941
8564 u http://dx.doi.org/10.1111/joim.12941x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1370177/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164032
8564 8u https://doi.org/10.1111/joim.12941
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395731
8564 8u https://lup.lub.lu.se/record/27323e96-f084-4c65-9ed2-68c4c5907b08
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160986
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141917157

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