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Sökning: onr:"swepub:oai:DiVA.org:umu-166486" > One-carbon metaboli...

  • Vrieling, AlinaRadboud University Nijmegen (författare)

One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-166486
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166486URI
  • https://doi.org/10.1002/ijc.32165DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141773165URI
  • https://lup.lub.lu.se/record/2968d6c3-1ca6-461f-b15c-c49940cff0b6URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bueno-De-Mesquita, H. BasUniversity of Malaya,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM),Imperial College London (författare)
  • Ros, Martine M.Radboud University Nijmegen,National Institute for Public Health and the Environment (RIVM) (författare)
  • Kampman, EllenWageningen University,Radboud University Nijmegen (författare)
  • Aben, Katja K.Netherlands Comprehensive Cancer Organisation (IKNL),Radboud University Nijmegen (författare)
  • Buchner, Frederike L.National Institute for Public Health and the Environment (RIVM) (författare)
  • Jansen, Eugene H.National Institute for Public Health and the Environment (RIVM) (författare)
  • Roswall, NinaDanish Cancer Society (författare)
  • Tjonneland, AnneDanish Cancer Society (författare)
  • Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy (författare)
  • Cadeau, ClaireInstitut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (författare)
  • Chang-Claude, JennyUniversity Medical Center Hamburg-Eppendorf,German Cancer Research Centre (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • Weikert, SteffenGerman Institute of Human Nutrition,Vivantes Humboldt Hospital (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (författare)
  • Lagiou, PagonaNational and Kapodistrian University of Athens,Harvard University,Academy of Athens (författare)
  • Trichopoulos, DimitriosHellenic Health Foundation, Athens,Harvard University,Academy of Athens (författare)
  • Sieri, SabinaIstituto Nazionale dei Tumori (författare)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Peeters, Petra H.Imperial College London,University Medical Center Utrecht (författare)
  • Weiderpass, ElisabeteKarolinska Institute,Karolinska Institutet,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,University of Helsinki (författare)
  • Skeie, GuriUiT The Arctic University of Norway, Tromsø (författare)
  • Jakszyn, PaulaCatalan Institute of Oncology (författare)
  • Chirlaque, Maria-DoloresCIBER Epidemiology and Public Health (CIBERESP),University of Murcia (författare)
  • Ardanaz, EvaCIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (författare)
  • Sanchez, Maria-JoseUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Ehrnström, RoySkåne University Hospital(Swepub:lu)pat-reh (författare)
  • Malm, JohanLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)klke-jma (författare)
  • Ljungberg, Börje,Professor,1949-Umeå University,Umeå universitet,Urologi och andrologi(Swepub:umu)bolj0001 (författare)
  • Khaw, Kay-TeeUniversity of Cambridge (författare)
  • Wareham, Nick J.University of Cambridge (författare)
  • Brennan, PaulInternational Agency for Research on Cancer, World Health Organization (författare)
  • Johansson, MattiasUmeå University,Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France,International Agency for Research on Cancer, World Health Organization(Swepub:umu)masmas97 (författare)
  • Riboli, ElioImperial College London (författare)
  • Kiemeney, Lambertus A.Radboud University Medical Center (författare)
  • Radboud University NijmegenUniversity of Malaya (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: John Wiley & Sons145:9, s. 2349-23590020-71361097-0215

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