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Asymmetric thinning...
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Roe, James M.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
(författare)
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-02-01
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Nature Research,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-180521
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180521URI
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https://doi.org/10.1038/s41467-021-21057-yDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Correction: Roe, J.M., Vidal-Piñeiro, D., Sørensen, Ø. et al. Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nat Commun 13, 834 (2022). DOI: 10.1038/s41467-022-28514-2
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Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Vidal-Piñeiro, DidacCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Sørensen, ØysteinCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Brandmaier, Andreas M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
(författare)
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Düzel, SandraCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
(författare)
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Gonzalez, Hector A.Center for Vital Longevity, University of Texas, TX, Dallas, United States
(författare)
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Kievit, Rogier A.MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
(författare)
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Knights, EthanMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
(författare)
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Kühn, SimoneCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Lindenberger, UlmanDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Mowinckel, Athanasia M.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Nyberg, Lars,1966-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001
(författare)
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Park, Denise C.Center for Vital Longevity, University of Texas, TX, Dallas, United States
(författare)
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Pudas, Sara,Fil. Dr.1983-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)saatus02
(författare)
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Rundle, Melissa M.Center for Vital Longevity, University of Texas, TX, Dallas, United States
(författare)
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Walhovd, Kristine B.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
(författare)
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Fjell, Anders M.Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
(författare)
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Westerhausen, RenéCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, NorwayCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Communications: Nature Research12:12041-1723
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Roe, James M.
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Vidal-Piñeiro, D ...
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Sørensen, Øystei ...
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Brandmaier, Andr ...
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Düzel, Sandra
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Gonzalez, Hector ...
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Kievit, Rogier A ...
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Knights, Ethan
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Kühn, Simone
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Lindenberger, Ul ...
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Park, Denise C.
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Pudas, Sara, Fil ...
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Rundle, Melissa ...
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Walhovd, Kristin ...
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Fjell, Anders M.
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Westerhausen, Re ...
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