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Perinatal famine is...
Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes
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- Fedotkina, Olena (författare)
- Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway
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- Luk, Andrea (författare)
- Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
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- Jain, Ruchi (författare)
- Lund University,Lunds universitet,Öcellsfysiologi,Forskargrupper vid Lunds universitet,Islet cell physiology,Lund University Research Groups,Skåne University Hospital
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- Prasad, Rashmi B (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Shungin, Dmitry (författare)
- Umeå University,Umeå universitet,Institutionen för odontologi,Broad Institute of Harvard and MIT, MA, Cambridge, United States
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- Simó-Servat, Olga (författare)
- Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona
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- Özgümüs, Türküler (författare)
- Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway
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- Cherviakova, Liubov (författare)
- Chernihiv Regional Hospital, Chernihiv, Ukraine
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- Khalimon, Nadiya (författare)
- City Hospital No 2, Chernihiv, Ukraine
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- Svietleisha, Tetiana (författare)
- City Hospital No 1, Chernihiv, Ukraine
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- Buldenko, Tetiana (författare)
- Department of Health Care of Chernihiv Regional State Administration, Chernihiv, Ukraine
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- Kravchenko, Victor (författare)
- Komisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine,V. P. Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences
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- Hernández, Cristina (författare)
- Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona
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- Jain, Deepak (författare)
- Lund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Medicinsk proteinvetenskap,Antigen Presentation,Lund University Research Groups,Medical Protein Science,Skåne University Hospital
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- Simo, Rafael (författare)
- Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona
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- Artner, Isabella (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Peter M (författare)
- Lund University,Lunds universitet,Enheten för medicinens historia,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,History of Medicine,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Khalangot, Mykola D. (författare)
- Komisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine; Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,V. P. Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences
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- Vaiserman, Alexander M. (författare)
- Laboratory of Epigenetics, Chebotarev Institute of Gerontology, Kyiv, Ukraine,Dmitry F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine
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- Chan, Juliana (författare)
- Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
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- Vaag, Allan (författare)
- Steno Diabetes Center Copenhagen, Copenhagen, Denmark
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- Lyssenko, Valeriya (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Bergen,Skåne University Hospital
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(creator_code:org_t)
- 2021-06-24
- 2022
- Engelska.
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Ingår i: Acta Ophthalmologica. - : John Wiley & Sons. - 1755-375X .- 1755-3768. ; 100:2, s. e539-e545
- Relaterad länk:
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http://dx.doi.org/10...
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Purpose: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine on the risk of proliferative diabetic retinopathy (PDR).Methods: We studied the risk for PDR among type 2 diabetes patients exposed to perinatal famine in two independent cohorts: the Ukrainian National Diabetes Registry (UNDR) and the Hong Kong Diabetes Registry (HKDR). We analysed individuals born during the Great Famine (the Holodomor, 1932–1933) and the WWII (1941–1945) famine in 101 095 (3601 had PDR) UNDR participants. Among 3021 (251 had PDR) HKDR participants, we studied type 2 diabetes patients exposed to perinatal famine during the WWII Japanese invasion in 1942–1945.Results: During the Holodomor and WWII, perinatal famine was associated with a 1.76-fold (p = 0.019) and 3.02-fold (p = 0.001) increased risk of severe PDR in the UNDR. The risk for PDR was 1.66-fold elevated among individuals born in 1942 in the HKDR (p < 0.05). The associations between perinatal famine and PDR remained statistically significant after corrections for HbA1c in available 18 507 UNDR (padditive interaction < 0.001) and in 3021 HKDR type 2 diabetes patients (p < 0.05).Conclusion: In conclusion, type 2 diabetes patients, exposed to perinatal famine, have increased risk of PDR compared to those without perinatal famine exposure. Further studies are needed to understand the underlying mechanisms and to extend this finding to other diabetes complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- diabetic retinopathy
- famine
- intrauterine exposure
- microvasculature
- type 2 diabetes
- undernutrition
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- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fedotkina, Olena
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Luk, Andrea
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Jain, Ruchi
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Prasad, Rashmi B
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Shungin, Dmitry
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Simó-Servat, Olg ...
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visa fler...
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Özgümüs, Türküle ...
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Cherviakova, Liu ...
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Khalimon, Nadiya
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Svietleisha, Tet ...
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Buldenko, Tetian ...
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Kravchenko, Vict ...
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Hernández, Crist ...
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Jain, Deepak
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Simo, Rafael
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Artner, Isabella
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Nilsson, Peter M
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Khalangot, Mykol ...
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Vaiserman, Alexa ...
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Chan, Juliana
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Vaag, Allan
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Lyssenko, Valeri ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Acta Ophthalmolo ...
- Av lärosätet
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Umeå universitet
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Lunds universitet