Sökning: onr:"swepub:oai:DiVA.org:umu-187745" >
The Cerebrospinal F...
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features
-
- Griffiths, William J. (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
- Abdel-Khalik, Jonas (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
- Moore, Sarah F. (författare)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
-
visa fler...
-
- Wijeyekoon, Ruwani S. (författare)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
-
- Crick, Peter J. (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
- Yutuc, Eylan (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
- Farrell, Krista (författare)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
-
- Breen, David P. (författare)
- Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
-
- Williams-Gray, Caroline H. (författare)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
-
- Theofilopoulos, Spyridon (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
- Arenas, Ernest (författare)
- Karolinska Institutet
-
- Trupp, Miles (författare)
- Umeå universitet,Neurovetenskaper
-
- Barker, Roger A. (författare)
- Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
-
- Wang, Yuqin (författare)
- Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
-
visa färre...
-
(creator_code:org_t)
- 2021-08-30
- 2021
- Engelska.
-
Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365. ; 13
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://www.frontier...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- bile acid biosynthesis
- dihydroxycholesterol
- mass spectrometry
- oxysterol
- sterol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Griffiths, Willi ...
-
Abdel-Khalik, Jo ...
-
Moore, Sarah F.
-
Wijeyekoon, Ruwa ...
-
Crick, Peter J.
-
Yutuc, Eylan
-
visa fler...
-
Farrell, Krista
-
Breen, David P.
-
Williams-Gray, C ...
-
Theofilopoulos, ...
-
Arenas, Ernest
-
Trupp, Miles
-
Barker, Roger A.
-
Wang, Yuqin
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Frontiers in Agi ...
- Av lärosätet
-
Umeå universitet
-
Karolinska Institutet