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Comparative analysi...
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Ning, YujieSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-05-30
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BioMed Central,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-195579
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-195579URI
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https://doi.org/10.1186/s13075-022-02819-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.Methods: Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing. To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria between OA and KBD groups, metagenomic sequencing of fecal samples from OA and KBD subjects was performed.Results: The OA group was characterized by elevated Epsilonbacteraeota and Firmicutes levels. A total of 52 genera were identified to be significantly differentially abundant between the two groups. The genera Raoultella, Citrobacter, Flavonifractor, g__Lachnospiraceae_UCG-004, and Burkholderia-Caballeronia-Paraburkholderia were more abundant in the OA group. The KBD group was characterized by higher Prevotella_9, Lactobacillus, Coprococcus_2, Senegalimassilia, and Holdemanella. The metagenomic sequencing showed that the Subdoligranulum_sp._APC924/74, Streptococcus_parasanguinis, and Streptococcus_salivarius were significantly increased in abundance in the OA group compared to those in the KBD group, and the species Prevotella_copri, Prevotella_sp._CAG:386, and Prevotella_stercorea were significantly decreased in abundance in the OA group compared to those in the KBD group by using metagenomic sequencing.Conclusion: Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Minhan, HuSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Yi, GongSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Ruitian, HuangSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Ke, XuDepartment of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
(författare)
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Sijie, ChenSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Feiyu, ZhangSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Yanli, LiuSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Feihong, ChenSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Yanhai, ChangShaanxi Provincial People’s Hospital, Xi’an, People’s Republic of China
(författare)
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Guanghui, ZhaoDepartment of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
(författare)
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Cheng, LiShaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
(författare)
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Rong, ZhouShaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
(författare)
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Lammi, Mikko,1961-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China,Chondrogeni and osteogenic differentiation(Swepub:umu)mila0077
(författare)
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Xiong, GuoSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
(författare)
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Xi, WangSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China; Department of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China; Global Health Institute, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
(författare)
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School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of ChinaDepartment of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
(creator_code:org_t)
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Ingår i:Arthritis Research & Therapy: BioMed Central24:11478-6362
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- Av författaren/redakt...
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Ning, Yujie
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Minhan, Hu
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Yi, Gong
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Ruitian, Huang
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Ke, Xu
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Sijie, Chen
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visa fler...
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Feiyu, Zhang
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Yanli, Liu
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Feihong, Chen
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Yanhai, Chang
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Guanghui, Zhao
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Cheng, Li
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Rong, Zhou
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Lammi, Mikko, 19 ...
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Xiong, Guo
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Xi, Wang
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