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Oral Microbiota Pro...
Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis
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- Esberg, Anders (författare)
- Umeå University,Umeå universitet,Institutionen för odontologi,Umeå Univ, Dept Odontol, S-90187 Umeå, Sweden.
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- Johansson, Linda (författare)
- Umeå University,Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med Rheumatol, S-90185 Umeå, Sweden.
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- Berglin, Ewa, MD, PhD, 1955- (författare)
- Umeå University,Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med Rheumatol, S-90185 Umeå, Sweden.
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- Mohammad, Aladdin J. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Vasculitis Epidemiology Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,University of Cambridge
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- Jonsson, Andreas P. (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, S-90185 Umeå, Sweden.
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- Dahlqvist, Johanna, 1979- (författare)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Reumatologi
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- Stegmayr, Bernd, 1949- (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, S-90185 Umeå, Sweden.
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- Johansson, Ingegerd (författare)
- Umeå University,Umeå universitet,Institutionen för odontologi,Umeå Univ, Dept Odontol, S-90187 Umeå, Sweden.
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå University,Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med Rheumatol, S-90185 Umeå, Sweden.
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(creator_code:org_t)
- 2022-08-04
- 2022
- Engelska.
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Ingår i: Microorganisms. - : MDPI. - 2076-2607. ; 10:8
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- anti-neutrophil cytoplasmatic antibody–associated vasculitis
- caries
- granulomatosis with polyangiitis (GPA)
- IgG
- microscopic polyangiitis (MPA)
- myeloperoxidase (MPO)-ANCA
- oral microbiota
- periodontal disease
- proteinase 3 (PR3)-ANCA
- vasculitis
- anti-neutrophil cytoplasmatic antibody–associated vasculitis
- caries
- granulomatosis with polyangiitis (GPA)
- IgG
- microscopic polyangiitis (MPA)
- myeloperoxidase (MPO)-ANCA
- oral microbiota
- periodontal disease
- proteinase 3 (PR3)-ANCA
- vasculitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Esberg, Anders
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Johansson, Linda
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Berglin, Ewa, MD ...
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Mohammad, Aladdi ...
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Jonsson, Andreas ...
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Dahlqvist, Johan ...
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Stegmayr, Bernd, ...
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Johansson, Ingeg ...
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Rantapää-Dahlqvi ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Medicinsk biotek ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
- Artiklar i publikationen
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Microorganisms
- Av lärosätet
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Umeå universitet
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Uppsala universitet
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Lunds universitet