Sökning: onr:"swepub:oai:DiVA.org:umu-202430" >
GBA and APOE impact...
GBA and APOE impact cognitive decline in Parkinson's disease : A 10-year population-based study
-
Szwedo, Aleksandra A (författare)
-
Dalen, Ingvild (författare)
-
Pedersen, Kenn Freddy (författare)
-
visa fler...
-
Camacho, Marta (författare)
-
- Bäckström, David C, M.D. 1978- (författare)
- Umeå universitet,Neurovetenskaper,Department of Neurology, and Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA
-
- Forsgren, Lars (författare)
- Umeå universitet,Neurovetenskaper
-
Tzoulis, Charalampos (författare)
-
Winder-Rhodes, Sophie (författare)
-
Hudson, Gavin (författare)
-
Liu, Ganqiang (författare)
-
Scherzer, Clemens R (författare)
-
Lawson, Rachael A (författare)
-
Yarnall, Alison J (författare)
-
Williams-Gray, Caroline H (författare)
-
Macleod, Angus D (författare)
-
Counsell, Carl E (författare)
-
Tysnes, Ole-Bjørn (författare)
-
Alves, Guido (författare)
-
Maple-Grødem, Jodi (författare)
-
visa färre...
-
(creator_code:org_t)
- 2022-02-02
- 2022
- Engelska.
-
Ingår i: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257. ; 37:5, s. 1016-1027
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Common genetic variance in apolipoprotein E (APOE), β-glucocerebrosidase (GBA), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) has been linked to cognitive decline in Parkinson's disease (PD), although studies have yielded mixed results.OBJECTIVES: To evaluate the effect of genetic variants in APOE, GBA, MAPT, and SNCA on cognitive decline and risk of dementia in a pooled analysis of six longitudinal, non-selective, population-based cohorts of newly diagnosed PD patients.METHODS: 1002 PD patients, followed for up to 10 years (median 7.2 years), were genotyped for at least one of APOE-ε4, GBA mutations, MAPT H1/H2, or SNCA rs356219. We evaluated the effect of genotype on the rate of cognitive decline (Mini-Mental State Examanation, MMSE) using linear mixed models and the development of dementia (diagnosed using standardized criteria) using Cox regression; multiple comparisons were accounted for using Benjamini-Hochberg corrections.RESULTS: Carriers of APOE-ε4 (n = 281, 29.7%) and GBA mutations (n = 100, 10.3%) had faster cognitive decline and were at higher risk of progression to dementia (APOE-ε4, HR 3.57, P < 0.001; GBA mutations, HR 1.76, P = 0.001) than non-carriers. The risk of cognitive decline and dementia (HR 5.19, P < 0.001) was further increased in carriers of both risk genotypes (n = 23). No significant effects were observed for MAPT or SNCA rs356219.CONCLUSIONS: GBA and APOE genotyping could improve the prediction of cognitive decline in PD, which is important to inform the clinical trial selection and potentially to enable personalized treatment © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- APOE
- GBA
- Parkinson's disease
- cognitive decline
- dementia
- Human Anatomy
- anatomi
- nanomaterials
- nanomaterial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Szwedo, Aleksand ...
-
Dalen, Ingvild
-
Pedersen, Kenn F ...
-
Camacho, Marta
-
Bäckström, David ...
-
Forsgren, Lars
-
visa fler...
-
Tzoulis, Charala ...
-
Winder-Rhodes, S ...
-
Hudson, Gavin
-
Liu, Ganqiang
-
Scherzer, Clemen ...
-
Lawson, Rachael ...
-
Yarnall, Alison ...
-
Williams-Gray, C ...
-
Macleod, Angus D
-
Counsell, Carl E
-
Tysnes, Ole-Bjør ...
-
Alves, Guido
-
Maple-Grødem, Jo ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Movement Disorde ...
- Av lärosätet
-
Umeå universitet