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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 16301naa a2201213 4500 | |
| 001 | oai:DiVA.org:umu-214290 | |
| 003 | SwePub | |
| 008 | 230911s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2142902 URI |
| 024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-23-04532 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a King, Sontoria D.u Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico4 aut |
| 245 | 1 0 | a Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization |
| 264 | 1 | b American Association For Cancer Research (AACR),c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer.METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes.RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample.CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk.IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Veliginti, Swathiu Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico4 aut |
| 700 | 1 | a Brouwers, Martijn C G Ju Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands4 aut |
| 700 | 1 | a Ren, Zhewenu Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands4 aut |
| 700 | 1 | a Zheng, Weiu Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, TN, Nashville, United States4 aut |
| 700 | 1 | a Setiawan, Veronica W.u Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Wilkens, Lynne R.u Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States4 aut |
| 700 | 1 | a Shu, Xiao-Ouu Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, TN, Nashville, United States4 aut |
| 700 | 1 | a Arslan, Alan A.u Departments of Obstetrics and Gynecology, Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, NY, United States4 aut |
| 700 | 1 | a Beane Freeman, Laura E.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Bracci, Paige M.u Department of Epidemiology and Biostatistics, University of California, CA, San Francisco, United States4 aut |
| 700 | 1 | a Canzian, Federicou Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
| 700 | 1 | a Du, Mengmengu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States4 aut |
| 700 | 1 | a Gallinger, Steven J.u Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, ON, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, ON, Toronto, Canada4 aut |
| 700 | 1 | a Giles, Graham G.u Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, VIC, Melbourne, Australia4 aut |
| 700 | 1 | a Goodman, Phyllis J.u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Haiman, Christopher A.u Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Kogevinas, Manolisu Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain4 aut |
| 700 | 1 | a Kooperberg, Charlesu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a LeMarchand, Loicu Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States4 aut |
| 700 | 1 | a Neale, Rachel E.u Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia4 aut |
| 700 | 1 | a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins School of Public Health, MD, Baltimore, Liberia; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia4 aut |
| 700 | 1 | a White, Emilyu Cancer Prevention Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Andreotti, Gabriellau Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Babic, Anau Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States4 aut |
| 700 | 1 | a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Brais, Lauren K.u Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States4 aut |
| 700 | 1 | a Brennan, Paulu Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France4 aut |
| 700 | 1 | a Buring, Julie E.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States4 aut |
| 700 | 1 | a Rabe, Kari G.u Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States4 aut |
| 700 | 1 | a Bamlet, William R.u Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States4 aut |
| 700 | 1 | a Chanock, Stephen J.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Fuchs, Charles S.u Yale Cancer Center, CT, New Haven, United States; Department of Medicine, Yale School of Medicine, CT, New Haven, United States; Smilow Cancer Hospital, CT, New Haven, United States4 aut |
| 700 | 1 | a Gaziano, J Michaelu Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States; Boston Veteran Affairs Healthcare System, MA, Boston, United States4 aut |
| 700 | 1 | a Giovannucci, Edward L.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States4 aut |
| 700 | 1 | a Hackert, Thilou Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany4 aut |
| 700 | 1 | a Hassan, Manal M.u Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut |
| 700 | 1 | a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
| 700 | 1 | a Kurtz, Robert C.u Gastroenterology, Hepatology, Nutrition Service, Memorial Sloan Kettering Cancer Center, NY, United States4 aut |
| 700 | 1 | a Lee, I-Minu Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States4 aut |
| 700 | 1 | a Malats, Núriau Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain4 aut |
| 700 | 1 | a Murphy, Neilu Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France4 aut |
| 700 | 1 | a Oberg, Ann L.u Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, MN, Rochester, United States4 aut |
| 700 | 1 | a Orlow, Ireneu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States4 aut |
| 700 | 1 | a Porta, Miquelu Hospital del Mar Institute of Medical Research (IMIM), Universitat Autònoma de Barcelona, Spain4 aut |
| 700 | 1 | a Real, Francisco X.u Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain4 aut |
| 700 | 1 | a Rothman, Nathanielu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Sesso, Howard D.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States4 aut |
| 700 | 1 | a Silverman, Debra T.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Thompson, Ian M.u CHRISTUS Santa Rosa Hospital - Medical Center, TX, San Antonio, United States4 aut |
| 700 | 1 | a Wactawski-Wende, Jeanu Department of Epidemiology and Environmental Health, University of Buffalo, NY, Buffalo, United States4 aut |
| 700 | 1 | a Wang, Xiaoliangu Cancer Prevention Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Wentzensen, Nicolasu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Yu, Herbertu Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, HI, Honolulu, United States4 aut |
| 700 | 1 | a Zeleniuch-Jacquotte, Anneu Departments of Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, NY, United States4 aut |
| 700 | 1 | a Yu, Kaiu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Wolpin, Brian M.u Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States4 aut |
| 700 | 1 | a Duell, Eric J.u Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain4 aut |
| 700 | 1 | a Li, Donghuiu Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut |
| 700 | 1 | a Hung, Rayjean J.u Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, Canada4 aut |
| 700 | 1 | a Perdomo, Sandrau Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France4 aut |
| 700 | 1 | a McCullough, Marjorie L.u Department of Population Science, American Cancer Society, Atlanta, Georgia4 aut |
| 700 | 1 | a Freedman, Neal D.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Patel, Alpa V.u Department of Population Science, American Cancer Society, Atlanta, Georgia4 aut |
| 700 | 1 | a Peters, Ulrikeu Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Riboli, Eliou Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women's Hospital, MA, Boston, United States4 aut |
| 700 | 1 | a Sund, Malinu Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap4 aut0 (Swepub:umu)masu0021 |
| 700 | 1 | a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut |
| 700 | 1 | a Zhong, Junu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Van Den Eeden, Stephen K.u Division of Research, Northern California, Kaiser Permanente, CA, Oakland, United States; Department of Urology, University of California San Francisco, CA, San Francisco, United States4 aut |
| 700 | 1 | a Kraft, Peteru Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut |
| 700 | 1 | a Risch, Harvey A.u Department of Chronic Disease Epidemiology, Yale School of Public Health, CT, New Haven, United States4 aut |
| 700 | 1 | a Amundadottir, Laufey T.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Klein, Alison P.u Department of Epidemiology, Johns Hopkins School of Public Health, MD, Baltimore, Liberia; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, MD, Baltimore, Liberia4 aut |
| 700 | 1 | a Stolzenberg-Solomon, Rachael Z.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
| 700 | 1 | a Antwi, Samuel O.u Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, FL, Jacksonville, Puerto Rico4 aut |
| 710 | 2 | a Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, FL, Jacksonville, Puerto Ricob Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, FL, Jacksonville, Puerto Rico4 org |
| 773 | 0 | t Cancer Epidemiology, Biomarkers and Preventiond : American Association For Cancer Research (AACR)g 32:9, s. 1265-1269q 32:9<1265-1269x 1055-9965x 1538-7755 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214290 |
| 856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-23-0453 |
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