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Global effect of mo...
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Magnussen, ChristinaCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
(författare)
Global effect of modifiable risk factors on cardiovascular disease and mortality
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Massachusetts Medical Society,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-217718
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217718URI
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https://doi.org/10.1056/NEJMoa2206916DOI
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https://lup.lub.lu.se/record/bba5a231-6c1f-4eed-a0f9-b461172665b8URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
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Cardiology
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Cardiology General
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Coronary Disease/Myocardial Infarction
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Diabetes
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Endocrinology
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Hypertension
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Lipids
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Obesity
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Prevention
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Public Health
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Public Health General
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Cardiovascular Diseases
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Cohort Studies
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Diabetes Mellitus
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Female
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Humans
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Male
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Middle Aged
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Risk Factors
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Smoking
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high density lipoprotein cholesterol
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adult
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all cause mortality
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Article
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body mass
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cardiovascular disease
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cardiovascular mortality
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cohort analysis
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confidence interval
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controlled study
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current smoker
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death
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diabetes mellitus
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female
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follow up
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groups by age and sex
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human
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incidence
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major clinical study
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male
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middle aged
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prevalence
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proportional hazards model
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risk factor
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systolic blood pressure
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treatment outcome
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smoking
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(författare)
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Leong, Darryl P.Department of Medicine (Cardiology), McMaster University, Hamilton, Canada
(författare)
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Alegre-Diaz, JesusExperimental Medicine Research Unit, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
(författare)
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Amouyel, PhilippeUniversité de Lille, Inserm, Centre Hospitalier University de Lille, Institut Pasteur de Lille, UMR1167 RID-AGE Risk Factors and Molecular Determinants of Aging-Related Diseases, Epidemiology and Public Health Department, Lille, France
(författare)
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Aviles-Santa, LarissaDivision of Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, MD, Bethesda, United States
(författare)
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De Bacquer, DirkDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium
(författare)
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Ballantyne, Christie M.Department of Medicine, Baylor College of Medicine, TX, Houston, United States
(författare)
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Bernabé-Ortiz, AntonioCronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
(författare)
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Bobak, MartinDepartment of Epidemiology and Public Health, University College London, London, United Kingdom
(författare)
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Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
(författare)
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Carrillo-Larco, Rodrigo M.Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States
(författare)
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De Lemos, JamesDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, TX, Dallas, United States
(författare)
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Dobson, AnnetteSchool of Public Health, University of Queensland, Brisbane, Australia
(författare)
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Dörr, MarcusDepartment of Internal Medicine B, University Medicine Greifswald, Dzhk Partner Site Greifswald, Greifswald, Germany
(författare)
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Donfrancesco, ChiaraDepartment of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
(författare)
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Drygas, WojciechDepartment of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Lazarski University, Warsaw, Poland
(författare)
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Dullaart, Robin P.Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
(författare)
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Engström, G.Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(författare)
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Ferrario, Marco M.Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Ferrières, JeanDepartment of Cardiology, Inserm UMR1295, Toulouse Rangueil University Hospital, Toulouse, France
(författare)
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De Gaetano, GiovanniDepartment of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
(författare)
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Goldbourt, UriDepartment of Epidemiology, Tel Aviv University School of Public Health, Tel Aviv, Israel
(författare)
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Gonzalez, ClicerioCentro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico
(författare)
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Grassi, GuidoClinica Medica, University of Milano Bicocca, Milan, Italy
(författare)
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Hodge, Allison M.Division of Cancer Epidemiology, Cancer Council Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Australia
(författare)
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Hveem, KristianHunt (Trøndelag Health Study) Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Trondheim, Norway
(författare)
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Iacoviello, LiciaResearch Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
(författare)
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Ikram, M. KamranDepartment of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
(författare)
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Irazola, VilmaDepartment of Chronic Diseases, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina
(författare)
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Jobe, ModouMedical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
(författare)
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Jousilahti, PekkaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Kaleebu, PontianoMedical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
(författare)
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Kavousi, MaryamDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
(författare)
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Kee, FrankThe Centre for Public Health, Queens University Belfast, Belfast, United Kingdom
(författare)
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Khalili, DavoodPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran
(författare)
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Koenig, WolfgangDzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; German Heart Center, Technical University of Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
(författare)
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Kontsevaya, AnnaNational Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
(författare)
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Kuulasmaa, KariDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Lackner, Karl J.Institute of Clinical Chemistry and Laboratory Medicine, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany
(författare)
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Leistner, David M.University Heart and Vascular Center Frankfurt, Dzhk Partner Site Rhine Main, Frankfurt, Germany
(författare)
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Lind, LarsDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden
(författare)
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Linneberg, AllanDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
(författare)
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Lorenz, ThiessCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
(författare)
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Lyngbakken, Magnus NakremDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Malekzadeh, RezaLiver and Pancreaticobiliary Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
(författare)
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Malyutina, SofiaResearch Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
(författare)
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Mathiesen, Ellisiv B.Department of Clinical Medicine, University of Tromsø the Arctic University of Norway, Tromsø, Norway
(författare)
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Melander, OlleDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden
(författare)
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Metspalu, AndresEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
(författare)
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Miranda, J. JaimeCronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia
(författare)
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Moitry, MarieDepartment of Public Health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France
(författare)
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Mugisha, JosephMedical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
(författare)
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Nalini, MahdiMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
(författare)
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Nambi, VijayMichael E. DeBakey Veterans Affairs Hospital, Baylor College of Medicine, TX, Houston, United States
(författare)
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Ninomiya, ToshiharuDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
(författare)
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Oppermann, KarenSchool of Medicine, University of Passo Fundo, Passo Fundo, Brazil
(författare)
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D'Orsi, EleonoraDepartment of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianopolis, Brazil
(författare)
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Pająk, AndrzejDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
(författare)
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Palmieri, LuigiDepartment of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
(författare)
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Panagiotakos, DemosthenesSchool of Health Sciences and Education, Harokopio University, Athens, Greece
(författare)
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Perianayagam, ArokiasamyNational Council of Applied Economic Research, Delhi, India; International Institute for Population Sciences, Mumbai, India
(författare)
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Peters, AnnetteDzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
(författare)
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Poustchi, HosseinDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
(författare)
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Prentice, Andrew M.Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
(författare)
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Prescott, EvaDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
(författare)
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Risérus, UlfDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden
(författare)
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Salomaa, VeikkoDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
(författare)
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Sans, SusanaCatalan Department of Health, Barcelona, Spain,University Medical Center Hamburg-Eppendorf
(författare)
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Sakata, SatokoDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
(författare)
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Schöttker, BenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
(författare)
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Schutte, Aletta E.George Institute for Global Health, Sydney, Australia; School of Population Health, Kensington, Australia; Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa
(författare)
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Sepanlou, Sadaf G.Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
(författare)
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Sharma, Sanjib KumarDepartment of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
(författare)
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Shaw, Jonathan E.Baker Heart and Diabetes Institute, Melbourne, Australia
(författare)
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Simons, Leon A.University of New South Wales, Kensington, Australia
(författare)
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Söderberg, StefanUmeå universitet,Kardiologi,Avdelningen för medicin(Swepub:umu)stso0001
(författare)
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Tamosiunas, AbdonasLaboratory of Population Studies, Institute of Cardiology, Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania
(författare)
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Thorand, BarbaraInstitute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
(författare)
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Tunstall-Pedoe, HughCardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
(författare)
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Twerenbold, RaphaelCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
(författare)
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Vanuzzo, DiegoMonica (Monitoring Cardiovascular Diseases) Friuli Study Group, Udine, Italy
(författare)
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Veronesi, GiovanniResearch Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
(författare)
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Waibel, JuliaCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
(författare)
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Wannamethee, S. GoyaResearch Department of Primary Care and Population Health, University College London, London, United Kingdom
(författare)
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Watanabe, MasafumiGlobal Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
(författare)
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Wild, Philipp S.Preventive Cardiology and Preventive Medicine, Mainz, Germany; Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany; Institute for Molecular Biology, Mainz, Germany
(författare)
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Yao, YaoChina Center for Health Development Studies, National School of Development, Peking University, China; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China
(författare)
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Zeng, YiCenter for Healthy Aging and Development Studies, National School of Development, Peking University, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, NC, Durham, United States
(författare)
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Ziegler, AndreasCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Cardio-CARE, Davos, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
(författare)
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Blankenberg, StefanCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany; Cardio-CARE, Davos, Switzerland
(författare)
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Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, GermanyKardiovaskulär forskning - hypertoni
(creator_code:org_t)
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et al.
Sammanhörande titlar
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Ingår i:New England Journal of Medicine: Massachusetts Medical Society389:14, s. 1273-12850028-47931533-4406
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