Chlamydia trachomatis and Mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors

Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi,Ovarian Cancer Research Group (författare)

Previously included in thesis in manuscript form.
Objective: To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors.Methods: Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (), ovarian carcinoma (), or other pelvic malignancies () were matched to four healthy controls each.Results: Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer () in women with plasma samples obtained >1 year prior to diagnosis (). M. genitalium IgG antibodies were associated with borderline ovarian tumors ().Conclusion: Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
borderline tumors
Chlamydia trachomatis
cHSP60
Mycoplasma genitalium
ovarian cancer
Obstetrics and gynaecology
Obstetrik och gynekologi
obstetrik och gynekologi
Obstetrics and Gynaecology

Lundin, EvaUmeå universitet,Patologi,Ovarian Cancer Research Group(Swepub:umu)evlu0001 (författare)
Jurstrand, MargarethaClinical Research Centre, Örebro University Hospital, Örebro, Sweden (författare)
Kumlin, UrbanUmeå universitet,Virologi(Swepub:umu)urku0002 (författare)
Elgh, Fredrik,1957-Umeå universitet,Avdelningen för virologi(Swepub:umu)frkelh76 (författare)
Ohlson, NinaUmeå universitet,Patologi(Swepub:umu)niaohn95 (författare)
Ottander, UlrikaUmeå universitet,Obstetrik och gynekologi,Ovarian Cancer Research Group(Swepub:umu)ulaotr95 (författare)
Umeå universitetObstetrik och gynekologi (creator_code:org_t)

Ingår i:Infectious diseases in obstetrics and gynecology: Hindawi Publishing Corporation20111064-74491098-0997

Av författaren/redakt...: Idahl, Annika, 1 ...; Lundin, Eva; Jurstrand, Marga ...; Kumlin, Urban; Elgh, Fredrik, 1 ...; Ohlson, Nina; visa fler...; Ottander, Ulrika; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.