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Sökning: onr:"swepub:oai:DiVA.org:umu-26861" > Small-molecule inhi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004093naa a2200433 4500
001oai:DiVA.org:umu-26861
003SwePub
008091029s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-268612 URI
0247 a https://doi.org/10.1038/nchembio.2422 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cegelski, Lynetteu Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.4 aut
2451 0a Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
264 c 2009-10-25
264 1b Nature Publishing Group,c 2009
338 a print2 rdacarrier
500 a Published online 25 October 2009
520 a Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6, inhibited curli biogenesis in UPEC and prevented the in vitro polymerization of the major curli subunit protein CsgA. The curlicides FN075 and BibC6 share a common chemical lineage with other ring-fused 2-pyridones termed pilicides. Pilicides inhibit the assembly of type1pili, which are required for pathogenesis during urinary tract infection. Notably, the curlicides retained pilicide activities and inhibited both curli-dependent and type 1–dependent biofilms. Furthermore, pretreatment of UPEC with FN075 significantly attenuated virulence in a mouse model of urinary tract infection. Curli and type 1pili exhibited exclusive and independent roles in promoting UPEC biofilms, and curli provided a fitness advantage in vivo. Thus, the ability of FN075 to block the biogenesis of both curli and type 1pili endows unique anti-biofilm and anti-virulence activities on these compounds.
7001 a Pinkner, Jerome Su Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 aut
7001 a Hammer, Neal Du Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA4 aut
7001 a Cusumano, Corinne Ku Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 aut
7001 a Hung, Chia Su Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 aut
7001 a Chorell, Erik,d 1980-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)erkchl00
7001 a Åberg, Veronica,d 1976-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)veaabg97
7001 a Walker, Jennifer Nu Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 aut
7001 a Seed, Patrick Cu Departments of Pediatrics and Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA4 aut
7001 a Almqvist, Fredriku Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)fral0001
7001 a Chapman, Matthew Ru Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA4 aut
7001 a Hultgren, Scott Ju Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 aut
7102 a Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.b Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA4 org
7730 t Nature Chemical Biologyd : Nature Publishing Groupg 5:12, s. 913-919q 5:12<913-919x 1552-4450x 1552-4469
8564 u http://www.nature.com/nchembio/journal/vaop/ncurrent/abs/nchembio.242.htmly Nature Chemical Biology
8564 u https://europepmc.org/articles/pmc2838449?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26861
8564 8u https://doi.org/10.1038/nchembio.242

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