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- Domellöf, Magnus,1963-Umeå universitet,Pediatrik (författare)
Iron absorption in breast-fed infants : effects of age, iron status, iron supplements, and complementary foods.
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
- American Society for Clinical Nutrition,2002
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- LIBRIS-ID:oai:DiVA.org:umu-35001
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35001URI
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- Språk:engelska
- Sammanfattning på:engelska
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- BACKGROUND: Iron supplements are often recommended for older breast-fed infants, but little is known about factors affecting iron absorption from human milk or supplements. OBJECTIVE: We investigated the effects of age, iron status, and iron intake on iron absorption in healthy, term, breast-fed infants. DESIGN: Twenty-five infants were randomly assigned to receive either 1) iron supplements (1 mg x kg(-1) x d(-1)) from 4 to 9 mo of age, 2) placebo from 4 to 6 mo and iron supplements from 6 to 9 mo, or 3) placebo from 4 to 9 mo. Infants were exclusively breast-fed to 6 mo and partially breast-fed to 9 mo of age. Iron absorption was assessed by giving (58)Fe with mother's milk at 6 and 9 mo. Blood samples were obtained at 4, 6, and 9 mo, and complementary food intake was recorded at 9 mo. RESULTS: At 6 mo, mean (+/-SD) fractional iron absorption from human milk was relatively low (16.4 +/- 11.4%), with no significant difference between iron-supplemented and unsupplemented infants. At 9 mo, iron absorption from human milk remained low in iron-supplemented infants (16.9 +/- 9.3%) but was higher (P = 0.01) in unsupplemented infants (36.7 +/- 18.9%). Unexpectedly, iron absorption at 9 mo was not correlated with iron status but was significantly correlated with intake of dietary iron, including supplemental iron. CONCLUSIONS: Changes in the regulation of iron absorption between 6 and 9 mo enhance the infant's ability to adapt to a low-iron diet and provide a mechanism by which some, but not all, infants avoid iron deficiency despite low iron intakes in late infancy.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- Infants
- human milk
- breast milk
- nonheme-iron absorption
- stable isotopes
- iron status
- dietary iron intake
- complementary food
- iron supplements
- dietary regulator
- adaptation
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Lönnerdal, Bo (författare)
- Abrams, Steven A (författare)
- Hernell, Olle,1945-Umeå universitet,Pediatrik(Swepub:umu)olhe0002 (författare)
- Umeå universitetPediatrik (creator_code:org_t)
Sammanhörande titlar
- Ingår i:American Journal of Clinical Nutrition: American Society for Clinical Nutrition76:1, s. 198-2040002-91651938-3207
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