Sökning: onr:"swepub:oai:DiVA.org:umu-35184" >
Circulating levels ...
Circulating levels of insulin-like growth factor-I and risk of ovarian cancer.
-
- Lukanova, Annekatrin (författare)
- Umeå universitet,Näringsforskning
-
- Lundin, Eva (författare)
- Umeå universitet,Näringsforskning,Patologi
-
Toniolo, Paolo (författare)
-
visa fler...
-
Micheli, Andrea (författare)
-
Akhmedkhanov, Arslan (författare)
-
Rinaldi, Sabina (författare)
-
Muti, Paola (författare)
-
- Lenner, Per (författare)
- Umeå universitet,Onkologi
-
Biessy, Carine (författare)
-
Krogh, Vittorio (författare)
-
Zeleniuch-Jacquotte, Anne (författare)
-
Berrino, Franco (författare)
-
- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning
-
Riboli, Elio (författare)
-
Kaaks, Rudolf (författare)
-
visa färre...
-
(creator_code:org_t)
- 2002-09-17
- 2002
- Engelska.
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 101:6, s. 549-554
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Insulin-like growth factor (IGF)-I, a mitogenic and anti-apoptotic peptide, has been implicated in the development of several cancers. We hypothesized that high circulating IGF-I concentrations may be associated with an increased risk of ovarian cancer. A case-control study was nested within 3 prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). One hundred thirty-two women with primary invasive epithelial ovarian cancer diagnosed at least 1 year after blood donation were case subjects. For each case, 2 control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study. There was no association between IGF-I concentrations and ovarian cancer risk in the study group as a whole. In analyses restricted to subjects who had developed ovarian cancer at a young age (<55), circulating IGF-I was directly and strongly associated with ovarian cancer risk (OR = 4.97; 95% CI = 1.22-20.2 for the top vs. the bottom IGF-I tertile after adjustment for parity, BMI categories and smoking). There was no significant association of IGF binding protein-3 with ovarian cancer risk. We found a strong direct relationship between circulating IGF-I levels and risk of developing ovarian cancer before age 55. Additional, larger studies of this association are needed to provide more precise estimates of effect.
Nyckelord
- insulin-like growth factor-I
- insulin-like growth factor binding protein-3
- ovarian cancer
- cohort study
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lukanova, Anneka ...
-
Lundin, Eva
-
Toniolo, Paolo
-
Micheli, Andrea
-
Akhmedkhanov, Ar ...
-
Rinaldi, Sabina
-
visa fler...
-
Muti, Paola
-
Lenner, Per
-
Biessy, Carine
-
Krogh, Vittorio
-
Zeleniuch-Jacquo ...
-
Berrino, Franco
-
Hallmans, Göran
-
Riboli, Elio
-
Kaaks, Rudolf
-
visa färre...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Umeå universitet