Sökning: onr:"swepub:oai:DiVA.org:umu-36703" >
Childhood near-tetr...
-
Lemez, Petr1Department of Hematology and Blood Transfusion, Hospital Jihlava, Jihlava, Czech Republic
(författare)
Childhood near-tetraploid acute lymphoblastic leukemia : an EGIL study on 36 cases
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
-
2010-06-19
-
Wiley,2010
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-36703
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36703URI
-
https://doi.org/10.1111/j.1600-0609.2010.01493.xDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:121293179URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVES: Patients with near-tetraploid (karyotype: 81 - 103 chromosomes) acute lymphoblastic leukemia (NT-ALL) constitute about 1% of childhood ALL and data reported on them are limited and controversial. The aim of the study was to enlarge the knowledge on these rarely occurring ALL. METHODS: The members of the European Group for Immunophenotyping of Leukemias (EGIL) searched retrospectively their databases for NT-ALL patients. RESULTS: We collected data of 36 European children from seven European countries with NT-ALL diagnosed since 1992. All patients reached complete remission (CR) after induction chemotherapy. Their blasts were negative for peroxidase and BCR-ABL1. Ten children were diagnosed as T-cell ALL (T-ALL) EGIL categories (T-I n=2, T-II n=2, T-III n=3, T-IV n=3) and four displayed various structural chromosomal abnormalities. Eight of 10 T-ALL remained in 1st CR; one died in CR from sepsis and one is alive in 2nd CR. Median survival was 88 (7-213) months. B-cell precursor (BCP) ALL was diagnosed in 26 children. Thirteen were positive for ETV6-RUNX1 and are alive in 1st CR for 32-147 months. Ten children were ETV6-RUNX1 negative and remained in 1st CR for 16-163 months. One girl with hypodiploid and NT metaphases and ETV6-RUNX1-negative BCP-ALL and one of two boys with NT-BCP-ALL not examined for ETV6-RUNX1 died of infection after stem cell transplantation in 2nd/3rd CR. Secondary myelodysplastic syndrome developed in two patients with NT-BCP-ALL. CONCLUSIONS: Our data demonstrate immunophenotypic, cytogenetic, and molecular heterogeneity of NT-ALL and favorable prognosis of most NT-ALL across different immunophenotypic and/or genetic ALL subtypes.
Ämnesord och genrebeteckningar
-
Tetraploid acute lymphoblastic leukemia; polyploidy; childhood; classification; immunophenotyping; molecular genetics; prognosis
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Attarbaschi, AndisheKarolinska Institutet
(författare)
-
Béné, Marie CGEIL-Laboratoire d’Immunologie du CHU & Faculte´ de Me´ decine, Nancy, France
(författare)
-
Bertrand, YvesDepartment of Pediatric Hematology, Hopital Debrousse,
(författare)
-
Castoldi, GianluigiInstitute of Hematology, University of Ferrara, Ferrara, Italy
(författare)
-
Forestier, ErikUmeå universitet,Pediatrik(Swepub:umu)erfo0007
(författare)
-
Garand, RichardLaboratory of Hematology, University Hospitals, Nantes, France
(författare)
-
Haas, Oskar ASt. Anna Children’s Hospital, Vienna, Austria
(författare)
-
Kagialis-Girard, SandrineHematological Laboratory, Hopital Debrousse, Lyon, France
(författare)
-
Ludwig, Wolf-DieterDepartment of Hematology-Oncology-Tumor Biology, HELIOS Clinic, Berlin-Buch, Germany
(författare)
-
Matutes, EstellaDepartment of Haematological Oncology, Royal Marsden Hospital, London, UK
(författare)
-
Mejstríková, EsterDepartment of Pediatric Hematology and Oncology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic
(författare)
-
Pages, Marie-PierreHematological Laboratory, Hopital Debrousse, Lyon, France
(författare)
-
Pickl, WinfriedInstitute of Immunology, University of Vienna, Vienna, Austria
(författare)
-
Porwit, AnnaDepartment of Pathology, Karolinska University Hospital and Institute, Stockholm, Sweden
(författare)
-
Orfao, AlbertoServicio di Citometria, University of Salamanca, Salamanca, Spain
(författare)
-
Schabath, RichardDepartment of Hematology-Oncology-Tumor Biology, HELIOS Clinic, Berlin-Buch, Germany
(författare)
-
Starý, JanDepartment of Pediatric Hematology and Oncology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic
(författare)
-
Strobl, HerbertInstitute of Immunology, University of Vienna, Vienna, Austria
(författare)
-
Talmant, PascalineLaboratory of Hematology, University Hospitals, Nantes, France
(författare)
-
van't Veer, Mars BDaniel den Hoed Cancer Center, Rotterdam, The Netherlands
(författare)
-
Zemanová, ZuzanaCenter of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
(författare)
-
Karolinska Institutet1Department of Hematology and Blood Transfusion, Hospital Jihlava, Jihlava, Czech Republic
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:European Journal of Haematology: Wiley85:4, s. 300-3080902-44411600-0609
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lemez, Petr
-
Attarbaschi, And ...
-
Béné, Marie C
-
Bertrand, Yves
-
Castoldi, Gianlu ...
-
Forestier, Erik
-
visa fler...
-
Garand, Richard
-
Haas, Oskar A
-
Kagialis-Girard, ...
-
Ludwig, Wolf-Die ...
-
Matutes, Estella
-
Mejstríková, Est ...
-
Pages, Marie-Pie ...
-
Pickl, Winfried
-
Porwit, Anna
-
Orfao, Alberto
-
Schabath, Richar ...
-
Starý, Jan
-
Strobl, Herbert
-
Talmant, Pascali ...
-
van't Veer, Mars ...
-
Zemanová, Zuzana
-
visa färre...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Umeå universitet
-
Karolinska Institutet