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A randomised feasib...
A randomised feasibility/phase II study (SBG 2004-1) with dose-dense/tailored epirubicin, cyclophoshamide (EC) followed by docetaxel (T) or fixed dosed dose-dense EC/T versus T, doxorubicin and C (TAC) in node-positive breast cancer.
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- Margolin, Sara (författare)
- Karolinska Institutet,Karolinska Institute
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- Bengtsson, Nils-Olof (författare)
- Umeå universitet,Onkologi,Umea University Hospital
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- Carlsson, Lena (författare)
- Department of Oncology, Sundsvall Hospital, Sweden
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- Edlund, Per (författare)
- Department of Oncology, Gävle Hopsital, Sweden
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- Hellstrøm, Mats (författare)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
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- Karlsson, Per, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens University Hospital
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- Lidbrink, Elisabet (författare)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
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- Linderholm, Barbro, 1959 (författare)
- Östergötlands Läns Landsting,Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Onkologiska kliniken US
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- Lindman, Henrik (författare)
- Uppsala universitet,Enheten för onkologi,University Uppsala Hospital
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- Malmström, Per (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University Lund Hospital
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- Pettersson Skøld, Dagny (författare)
- Department of Oncology, Karolinska Institute and University Hospital, Stockholm, Sweden
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- Søderberg, Martin (författare)
- Department of Oncology, Malmø University Hospital, Sweden
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- Villman, Kenneth (författare)
- Department of Oncology, Örebro University Hospital, Sweden
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- Bergh, Jonas (författare)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- Informa Healthcare, 2011
- 2011
- Engelska.
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 50:1, s. 35-41
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aim of the study was to evaluate the feasibility of tailored and dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant breast cancer therapy. Material and methods. Patients with node-positive breast cancer received either four cycles of biweekly and tailored EC (epirubicin 38-60-75-90-105-120 mg/m(2), cyclophosphamide 450-600-900-1200 mg/m(2)) followed by four cycles of docetaxel (60-75-85-100 mg/m(2)) (arm A) or the same regimen with fixed doses (E(90)C(600) + 4 → T(75) + 4) (arm B) or docetaxel, doxorubicin and cyclophosphamide (T(75)A(50)C(500)) every three weeks for six cycles (arm C). All patients received G-CSF support and prophylactic ciprofloxacin. Results. One-hundred and twenty-four patients were randomised in the study. In the A, B and C arm, 17% 19% and 3% of the patients had one or more cycles delayed due to side-effects whereas 24%, 5% and 15% experienced a grade 3 infection or febrile neutropenia. After the introduction of an extra week between the EC and T parts in the A and B arms, grade 3 hand-foot-skin reactions were reduced from 5 to 0.2%. Twenty-nine percent (A and B) and 20% (C) of the patients were hospitalised due to side-effects. Discussion. Dose-dense and tailored EC/T can be given with manageable toxicity and is after adjustment presently studied in the phase III Panther trial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- onkologi
- Oncology
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Margolin, Sara
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Bengtsson, Nils- ...
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Carlsson, Lena
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Edlund, Per
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Hellstrøm, Mats
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Karlsson, Per, 1 ...
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Lidbrink, Elisab ...
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Linderholm, Barb ...
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Lindman, Henrik
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Malmström, Per
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Pettersson Skøld ...
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Søderberg, Marti ...
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Villman, Kenneth
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Bergh, Jonas
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Acta Oncologica
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Umeå universitet
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Lunds universitet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet
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