Sökning: onr:"swepub:oai:DiVA.org:umu-39542" > Non-proteolytic aer...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03981naa a2200409 4500 | |
001 | oai:DiVA.org:umu-39542 | |
003 | SwePub | |
008 | 110131s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:122656720 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-395422 URI |
024 | 7 | a https://doi.org/10.1159/0003187432 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1226567202 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Österlund, Camilla,d 1978-u Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)caaosd97 |
245 | 1 0 | a Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells |
264 | c 2010-12-22 | |
264 | 1 | b S. Karger AG,c 2011 |
338 | a print2 rdacarrier | |
520 | a Background: Exposure to seasonal or indoor allergens may cause sensitisation and development of allergic airway diseases. We have previously demonstrated that the non-proteolytic major house dust mite (HDM) allergen Der p 2 stimulates pro-inflammatory responses in bronchial epithelial cells. We aimed to determine if other clinically relevant non-proteolytic aeroallergens originating from HDMs, storage mites, cat, dog, birch and timothy also activate respiratory epithelial cells. Methods: Cultures of human bronchial epithelial cell line BEAS-2B, normal human bronchial epithelial cells and alveolar epithelial cell line A549 were exposed to recombinant (r)Der p 2, natural (n)Der f 2, rEur m 2, rLep d 2, rFel d 1, nFel d 1, rCan f 2, rBet v 1 or rPhl p 5a. A panel of secreted mediators and expression of cell adhesion receptors involved in recruitment, survival and adhesion of inflammatory cells in asthmatic airways was assessed. Results: The mite allergens rDer p 2, nDer f 2, rEur m 2 and rLep d 2 as well as the cat and dog allergens rFel d 1, nFel d 1 and rCan f 2 induced granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interleukin (IL)-6, IL-8, monocyte-chemotactic protein-1 and macrophage inflammatory protein-3α secretion from bronchial epithelial cells as well as surface expression of intracellular adhesion molecule-1. The pollen allergens rBet v 1 and rPhl p 5a from birch and timothy did not activate the cells. None of the studied allergens affected the alveolar epithelial cells. Conclusion: These results show that both mite and structurally unrelated cat and dog allergens can activate respiratory epithelial cells by adjuvant-like protease-independent mechanisms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a house-dust mite; factor-kappa-b; allergen fel-d-1; inflammatory response; lipocalin proteins; major allergen; amino-acid; asthma; lung; expression | |
700 | 1 | a Grönlund, Hansu Karolinska Institutet4 aut |
700 | 1 | a Gafvelin, Gurou Karolinska Institutet4 aut |
700 | 1 | a Bucht, Andersu Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)anbu0006 |
710 | 2 | a Umeå universitetb Lungmedicin4 org |
773 | 0 | t International Archives of Allergy and Immunologyd : S. Karger AGg 155:2, s. 111-118q 155:2<111-118x 1018-2438x 1423-0097 |
856 | 4 | u https://www.karger.com/Article/Pdf/318743 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39542 |
856 | 4 8 | u https://doi.org/10.1159/000318743 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122656720 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy