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Loss of hyaluronan ...
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Bertheim, UlfUmeå universitet,Institutionen för klinisk vetenskap
(författare)
Loss of hyaluronan in the basement membrane zone of the skin correlates to the degree of stiff hands in diabetes patients
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
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Medical Journals Sweden AB,2002
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-3988
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3988URI
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https://doi.org/10.1080/000155502320624041DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Glycosaminoglycans are important components of all extracellular matrices. One of the glycosaminoglycans is hyaluronan, which is ubiquitously distributed throughout the connective tissue. Hyaluronan is especially abundant in the skin, in which it is of both structural and functional importance. This study describes the localization and distribution of hyaluronan in the skin of healthy individuals and of 23 patients with insulin-dependent diabetes mellitus and various degrees of limited joint mobility. In normal skin, hyaluronan staining was seen in all layers but most prominently in the papillary dermis and the basement membrane zone. In the skin from diabetic patients with normal or only moderately restricted mobility of the hands (limited joint mobility grades 0 and 1), the distribution of hyaluronan was similar to that of normal skin. In the skin of patients with severe restriction in joint mobility (limited joint mobility grade 2) the staining pattern was significantly different with weak hyaluronan staining in the papillary dermis and the basement membrane zone almost devoid of hyaluronan. Moreover, an increased epidermal thickness in the latter patients was evident as well as a pronounced hyaluronan staining compared with normal epidermis.
Ämnesord och genrebeteckningar
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diabetes
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hyaluronan
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skin
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limited joint mobility
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Engström-Laurent, AnnaUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anen0001
(författare)
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Hofer, Per-ÅkeUmeå universitet,Dermatologi och venereologi
(författare)
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Hallgren, Peter
(författare)
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Asplund, Johan
(författare)
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Hellström, StenUmeå universitet,Öron- näs- och halssjukdomar
(författare)
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Umeå universitetInstitutionen för klinisk vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Dermato-Venereologica: Medical Journals Sweden AB82:5, s. 329-3340001-55551651-2057
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