Sökning: onr:"swepub:oai:DiVA.org:umu-41629" >
Tumor necrosis fact...
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Dossus, LaureDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk : the EPIC study
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-03-08
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Geneve :International union against cancer,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-41629
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41629URI
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https://doi.org/10.1002/ijc.25840DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Becker, SusenDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Rinaldi, SabinaSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(författare)
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Lukanova, AnnekatrinDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Tjønneland, AnneInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
(författare)
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Olsen, AnjaInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
(författare)
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Overvad, KimDepartment of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
(författare)
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Chabbert-Buffet, NathalieDepartment of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France
(författare)
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Boutron-Ruault, Marie-ChristineINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
(författare)
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Clavel-Chapelon, FrançoiseINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
(författare)
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Teucher, BirgitDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Pischon, TobiasDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
(författare)
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Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
(författare)
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Trichopoulou, AntoniaDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
(författare)
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Benetou, VasilikiDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
(författare)
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Valanou, ElisavetDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
(författare)
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Palli, DomenicoMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
(författare)
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Sieri, SabinaDepartment of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
(författare)
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Tumino, RosarioCancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy
(författare)
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Sacerdote, CarlottaCenter for Cancer Prevention (CPO Piedmont), Turin, Italy
(författare)
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Galasso, RoccoInstituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy
(författare)
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Redondo, Maria-LuísaPublic Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
(författare)
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Bonet Bonet, CatalinaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
(författare)
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Molina-Montes, EstherAndalusian School of Public Health, Granada, Spain
(författare)
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Altzibar, Jone MCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
(författare)
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Chirlaque, Maria-DoloresCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
(författare)
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Ardanaz, EvaCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
(författare)
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Bueno-de-Mesquita, H BasCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
(författare)
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van Duijnhoven, Fränzel J BNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
(författare)
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Peeters, Petra H MJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
(författare)
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Onland-Moret, N CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
(författare)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(författare)
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Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anid0002
(författare)
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Khaw, Kay-TeeDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
(författare)
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Wareham, NicholasMRC Epidemiology Unit, Cambridge, United Kingdom
(författare)
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Allen, NaomiNuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
(författare)
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Romieu, IsabelleInternational Agency for Research on Cancer, Lyon, France
(författare)
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Fedirko, VeronikaInternational Agency for Research on Cancer, Lyon, France
(författare)
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Hainaut, PierreDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
(författare)
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Romaguera, DoraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
(författare)
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Norat, TeresaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
(författare)
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Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
(författare)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of CancerGeneve : International union against cancer129:8, s. 2032-20370020-71361097-0215
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Dossus, Laure
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Becker, Susen
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Rinaldi, Sabina
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Lukanova, Anneka ...
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Tjønneland, Anne
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Olsen, Anja
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visa fler...
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Overvad, Kim
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Chabbert-Buffet, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Teucher, Birgit
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Chang-Claude, Je ...
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Pischon, Tobias
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vasilik ...
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Valanou, Elisave ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Galasso, Rocco
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Redondo, Maria-L ...
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Bonet Bonet, Cat ...
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Molina-Montes, E ...
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Altzibar, Jone M
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Chirlaque, Maria ...
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Ardanaz, Eva
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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Onland-Moret, N ...
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Lundin, Eva
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Idahl, Annika
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Allen, Naomi
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Romieu, Isabelle
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Fedirko, Veronik ...
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Hainaut, Pierre
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Romaguera, Dora
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Norat, Teresa
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Riboli, Elio
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Kaaks, Rudolf
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