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Insulin-like growth...
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Zachrisson, IKarolinska Institutet
(författare)
Insulin-like growth factor binding protein-1 as glucose regulator in adolescent boys with type 1 diabetes.
- Artikel/kapitelEngelska2000
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LIBRIS-ID:oai:DiVA.org:umu-45418
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45418URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1932167URI
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https://doi.org/10.1080/713794574DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The aim of the present study was to investigate whether the diurnal variability of B-Glucose is dependent on GH, IGF-I and IGFBP-1 levels, apart from insulin, and if there is any difference between Tanner stages 3 and 5. Five boys in Tanner stage 3 and 6 boys in stage 5 with type 1 diabetes were included. Blood was continuously collected from a cubital vein for 24 h. S-Insulin, S-GH, S-IGF-I and S-IGFBP-1 were analysed. B-Glucose was analysed hourly at bedside. One week before and 1 wk after the 24-h study period the participants performed self-monitoring of blood glucose (SMBG) during normal physiologic conditions. In the 24-h profile of B-Glucose, insulin, IGFBP-1 and GH, we found a significant positive correlation between B-Glucose and log IGFBP-1 (r = 0.5, p = 0.005) and an inverse correlation to insulin (r = -0.5, p = 0.004) but no correlation to logGH (r = -0.04, p = 0.831). In multiple regression analysis, B-Glucose was still significantly correlated to log IGFBP-1, when adjusting for insulin and GH, in Tanner stage 5. We found a difference between Tanner stages 3 and 5 in the variability of B-Glucose over a longer period during normal daily activity (p = 0.02), but not over the 24-h study period. CONCLUSION: We have demonstrated in type 1 diabetes adolescent boys a relationship between simultaneously measured blood-glucose and IGFBP-1 levels independent of the insulin and GH levels, suggesting that the free fraction of IGF-I influences the glucose metabolism.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dahlquist, Gisela,1944-Umeå universitet,Pediatrik(Swepub:umu)gida0001
(författare)
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Wallensteen, MAstrid Lindgren Children’s Hospital, Karolinska Hospital and Institute, Stockholm, Sweden
(författare)
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Brismar, KKarolinska Institutet
(författare)
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Karolinska InstitutetPediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Paediatrica89:9, s. 1044-90803-52531651-2227
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