Association of adipose tissue blood flow with fat depot sizes and adipokines in women

Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. International Journal of Obesity advance online publication, 26 July 2011; doi:10.1038/ijo.2011.152.

Karpe, FredrikNIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK (författare)
Sjöström, Lars-GöranUmeå universitet,Medicin(Swepub:umu)lasj0003 (författare)
Riklund, KatrineUmeå universitet,Diagnostisk radiologi(Swepub:umu)kaah0001 (författare)
Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001 (författare)
Olsson, TommyUmeå universitet,Medicin(Swepub:umu)tool0003 (författare)
Umeå universitetMedicin (creator_code:org_t)

Ingår i:International Journal of Obesity: Nature Publishing Group36:6, s. 783-7890307-05651476-5497

Av författaren/redakt...: Andersson, Jonas; Karpe, Fredrik; Sjöström, Lars-G ...; Riklund, Katrine; Söderberg, Stefa ...; Olsson, Tommy

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