Sökning: onr:"swepub:oai:DiVA.org:uu-107312" >
Enhanced susceptibi...
-
Nilsson, Kajsa E.Uppsala universitet,Institutionen för cell- och molekylärbiologi
(författare)
Enhanced susceptibility to low-dose collagen-induced arthritis in CR1/2-deficient female mice : possible role of estrogen on CR1 expression
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
2009-04-07
-
Wiley,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-107312
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107312URI
-
https://doi.org/10.1096/fj.08-125849DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The influence of complement receptor 1 and 2 (CR1/2) was investigated on the susceptibility to low-dose collagen-induced arthritis (CIA) in wild-type (WT) and CR1/2-deficient DBA/1 mice. Significantly enhanced CIA was observed in female CR1/2-deficient mice compared with WT female mice, while male mutant and WT mice showed similar arthritis development. The enhanced CIA was accompanied with higher complement levels and a prolonged IgM anti-collagen type II response. When investigating whether estrogen contributed to the different arthritis susceptibility, we found that ovariectomy rendered WT females more sensitive to low-dose CIA and to the same extent as CR1/2-deficient females, while CR1/2-deficient mice were unaffected by ovariectomy. Notably, the ovariectomized WT mice displayed reduced CR1(+) B220(+) B-cell numbers and CR1 expression compared with sham-operated WT mice, suggesting a stimulatory effect of estrogen on CR1. In accordance, a significant correlation was observed between reduced CR1 expression in B cells and increased age in healthy female blood donors but not in male donors. Our findings demonstrate an important role of CR1/2 in suppressing CIA in female mice under low-antigen conditions. The data suggest that estrogen promote CR1 expression in B cells. These findings provide insight to the increased frequency of rheumatoid arthritis in postmenopausal women.
Ämnesord och genrebeteckningar
-
complement receptor
-
B cells
-
knockout mice
-
autoimmunity
-
MEDICINE
-
MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Andrén, MariaUppsala universitet,Institutionen för cell- och molekylärbiologi
(författare)
-
Diaz de Ståhl, TeresitaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)testahl
(författare)
-
Kleinau, SandraUppsala universitet,Institutionen för cell- och molekylärbiologi(Swepub:uu)sandklei
(författare)
-
Uppsala universitetInstitutionen för cell- och molekylärbiologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:The FASEB Journal: Wiley23:8, s. 2450-24580892-66381530-6860
Internetlänk
Hitta via bibliotek
Till lärosätets databas