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Effect of excluding...
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Sundqvist, MartinUppsala universitet,Infektionssjukdomar
(författare)
Effect of excluding duplicate isolates of Escherichia coli and Staphylococcus aureus in a 14 year consecutive database
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-03-01
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Oxford University Press (OUP),2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-112600
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112600URI
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https://doi.org/10.1093/jac/dkm040DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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OBJECTIVES: It is recommended that duplicate isolates are excluded when reporting resistance rates. The rationale for this is that failing to do so will yield falsely high resistance rates. We analysed a 14 year consecutive database of Escherichia coli (n=62,380) and Staphylococcus aureus (n=28,178) using various cut-off algorithms to determine the importance of excluding duplicates and principal differences between the bacteria. METHODS: Susceptibility testing was performed according to the Swedish Reference Group for Antibiotics guidelines. Duplicates were excluded on the basis of species, individual and time (exclusion cut-offs of 7, 14, 30, 45, 90, 180, 270 and 365 days) from the first isolate. RESULTS: Although 30% of the isolates were excluded using a 365 day exclusion algorithm, the effects on resistance rates of excluding duplicates were small. Irrespective of cut-off, resistance in S. aureus decreased when duplicates were excluded. Using 7-30 days cut-offs, resistance in E. coli decreased or was not affected, whereas higher resistance rates were obtained when exclusion was based on a 365 day cut-off. Fluoroquinolone resistance was a clear exception to this rule. CONCLUSIONS: Although the effect of exclusion of duplicates was minor, we suggest that exclusion cut-offs should match the study timeline. The data presented on E. coli, from urinary tract infections, and S. aureus, from skin and soft tissue infections, suggest that E. coli infection, >90 days after the first culture, is mainly caused by new less-resistant strains. Patients with S. aureus continue to be colonized with the same strain.
Ämnesord och genrebeteckningar
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antimicrobial resistance
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surveillance
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urinary tract infections
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skin and soft tissue infections
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kahlmeter, GunnarUppsala universitet,Klinisk bakteriologi(Swepub:uu)gunka977
(författare)
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Uppsala universitetInfektionssjukdomar
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Antimicrobial Chemotherapy: Oxford University Press (OUP)59:5, s. 913-9180305-74531460-2091
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